Jakob Johann von Uexküll was born in Keblaste (now Mihkli), Estonia, in September 8, 1864, and died on the island of Capri in July 25, 1944.
He studied zoology in the University of Tartu (then Dorpat), Estonia, in 1884-89. After this, he worked at the Institute of Physiology of the University of Heidelberg (in the group of Wilhelm Kühne (1837-1900), who was the editor-in-chief of the leading European biological journal Zeitschrift für Biologie, and the author of the notion enzyme), and at the Zoological Station in Naples. In 1907 he was given an honorary doctorate by the University of Heidelberg for his studies in the field of muscular physiology. One of his results of these years became known as Uexküll's law, which is probably one of the first formulations of the principle of negative feedback occurring inside an organism.