Inaugural lecture by Jyrki Heinämäki on recent developments in the manufacture of pharmaceuticals
12.05.2011
The University of Tartu is Inaugural Lectures Series continues with a presentation by Jyrki Heinämäki, UT Professor of Medical Technology, on "Building Quality into Medicinal Products through Design and Understanding of Manufacturing Processes“, the lecture will be held on 19 May 2011 at 4:15 pm in the UT History Museum.
The manufacturing of medicinal products is a challenging and rapidly developing high-tech branch of pharmaceutical industry. The manufacturing processes often represent highly complex multivariable operations during which several interrelated phenomena take place simultaneously. This creates formidable challenges in providing quality medicinal products to the public.
The inaugural lecture will highlight recent developments and future perspectives in solid dosage manufacturing of pharmaceuticals. Process analytical technology (PAT) approach will be used to stress the significance of process understanding and continuous process improvement.
Manufacturing operations such as grinding, wet granulation, drying, tablet compression and tablet film coating may be accompanied by process induced transformations (PITs) in solid dosage material. The PITs associated with these process steps are well known but difficult to predict and often difficult to control.
The lecture will discuss recently developed process imaging and spectroscopic techniques as new PAT tools that allow real time and continuous monitoring of manufacturing processes and also permit eventual PITs to be identified.
Professor Jyrki Heinämäki received his PhD degree at the University of Helsinki in 1991 and was appointed docent in pharmaceutical technology in 1995. After serving as a senior researcher in the National Agency for Medicines, he worked at the University of Helsinki as head assistant, senior lecturer and principal investigator from 1997 - 2010.
Professor Heinämäki has considerable experience in research and international collaboration on pharmaceutical solid dosage manufacturing processes and process analytical technology (PAT). He has been supervisor of a total of 13 PhD students who have successfully defended their theses at the University of Helsinki and abroad. He is also the author or co-author of more than 80 original research manuscripts.
His research group has received a number of awards and stipendiary support for formulation and process research on solid dosage manufacturing. Professor Heinämäki is also one of the charter members of Pharmaceutical Solid State Research Cluster (PSSRC) which was founded by eight international research centres in 2006. Since 1995, he has also acted as a Scientific Advisor of the European Medicines Agency (EMA) and Scientific Advisor and Consultant of Finnish Medicines Agency, FIMEA.
He holds an honorary professorship at the University of Havana, Cuba since 2008. In September 2010, he was elected Professor of Medical Technology at the Department of Pharmacy, University of Tartu.
Professor Heinämäki’s research interests include pharmaceutical powder technology, particle surface engineering, granulation and pelletisation, tablet compression, pharmaceutical thin coatings, drug-excipient incompatibilities and process induced transformations (PITs).
Jyrki Heinamäki's professorship at the University of Tartu is supported by the European Social Fund through the DoRa Program Action 2. The aim of the doctoral studies and internationalization program DoRa 2 is to improve the quality of higher education by recruiting academic staff from abroad.
Additional information: Ms Kady Sõstar, public relations specialist, tel. +372 737 5685, e-mail: kady [dot] sostar [ät] ut [dot] ee
The manufacturing of medicinal products is a challenging and rapidly developing high-tech branch of pharmaceutical industry. The manufacturing processes often represent highly complex multivariable operations during which several interrelated phenomena take place simultaneously. This creates formidable challenges in providing quality medicinal products to the public.
The inaugural lecture will highlight recent developments and future perspectives in solid dosage manufacturing of pharmaceuticals. Process analytical technology (PAT) approach will be used to stress the significance of process understanding and continuous process improvement.
Manufacturing operations such as grinding, wet granulation, drying, tablet compression and tablet film coating may be accompanied by process induced transformations (PITs) in solid dosage material. The PITs associated with these process steps are well known but difficult to predict and often difficult to control.
The lecture will discuss recently developed process imaging and spectroscopic techniques as new PAT tools that allow real time and continuous monitoring of manufacturing processes and also permit eventual PITs to be identified.
Professor Jyrki Heinämäki received his PhD degree at the University of Helsinki in 1991 and was appointed docent in pharmaceutical technology in 1995. After serving as a senior researcher in the National Agency for Medicines, he worked at the University of Helsinki as head assistant, senior lecturer and principal investigator from 1997 - 2010.
Professor Heinämäki has considerable experience in research and international collaboration on pharmaceutical solid dosage manufacturing processes and process analytical technology (PAT). He has been supervisor of a total of 13 PhD students who have successfully defended their theses at the University of Helsinki and abroad. He is also the author or co-author of more than 80 original research manuscripts.
His research group has received a number of awards and stipendiary support for formulation and process research on solid dosage manufacturing. Professor Heinämäki is also one of the charter members of Pharmaceutical Solid State Research Cluster (PSSRC) which was founded by eight international research centres in 2006. Since 1995, he has also acted as a Scientific Advisor of the European Medicines Agency (EMA) and Scientific Advisor and Consultant of Finnish Medicines Agency, FIMEA.
He holds an honorary professorship at the University of Havana, Cuba since 2008. In September 2010, he was elected Professor of Medical Technology at the Department of Pharmacy, University of Tartu.
Professor Heinämäki’s research interests include pharmaceutical powder technology, particle surface engineering, granulation and pelletisation, tablet compression, pharmaceutical thin coatings, drug-excipient incompatibilities and process induced transformations (PITs).
Jyrki Heinamäki's professorship at the University of Tartu is supported by the European Social Fund through the DoRa Program Action 2. The aim of the doctoral studies and internationalization program DoRa 2 is to improve the quality of higher education by recruiting academic staff from abroad.
Additional information: Ms Kady Sõstar, public relations specialist, tel. +372 737 5685, e-mail: kady [dot] sostar [ät] ut [dot] ee