Study: new gene variations affecting heart rate to serve as a basis for a better treatment and prevention of heart disease | University of Tartu
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Jakobi 2 - 116-121, 51014, Tartu
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    Jakobi 2, 51003, Tartu
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    Jakobi 2, III, rooms 309-352, 51014, Tartu
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    Ülikooli 18-310, 50090, Tartu
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    Lossi 3, 51003, Tartu
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    Posti 1, 71004, Viljandi
Faculty of Social Sciences
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(+372) 737 5957
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Lossi 36, 51003, Tartu
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    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003, Tartu
  • Institute of Education
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    Salme 1a, room 29, 50103, Tartu
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    Lossi 36, roomm 301, 51003, Tartu
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    J. Liivi 4, 50409, Tartu
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    Näituse 2, 50409, Tartu
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    Näituse 20, 50409, Tartu
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    Lossi 36, 51003, Tartu
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    Raekoja plats 2, 20307, Narva
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    Ringi 35, 80012, Pärnu
Faculty of Medicine
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Ravila 19, 50411, Tartu
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    Raekoja plats 6, 51003, Tartu
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    L. Puusepa 8, 51014, Tartu, Eesti
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    Ravila 19, 50411 Tartu
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    Jakobi 5-205, 51014, Tartu
Faculty of Science and Technology
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(+372) 737 5820
Faculty address: 
Vanemuise 46-208, 51014, Tartu
  • Dean's Office
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    Vanemuise 46 - 208, 51014, Tartu
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    J. Liivi 2, 50409, Tartu
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    Mäealuse 14, 12618, Tallinn
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    W. Ostwaldi Str 1, 50411, Tartu
  • Institute of Chemistry
    Faculty phone: 
    (+372) 737 5261
    Faculty address: 
    Ravila 14a, 50411, Tartu
  • Institute of Mathematics and Statistics
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    Faculty address: 
    J. Liivi 2, 50409, Tartu
  • Institute of Molecular and Cell Biology
    Faculty phone: 
    (+372) 737 5011
    Faculty address: 
    Riia 23, 23b-134, 51010, Tartu
  • Institute of Technology
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    Faculty address: 
    Nooruse 1, 50411, Tartu
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    Faculty address: 
    Vanemuise 46, 51014, Tartu
Institutions
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    Faculty address: 
    W.Struve 1, 50091, Tartu
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    Faculty address: 
    Lossi 38, 51003, Tartu
  • Estonian Genome Center
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    Riia 23b, 51010, Tartu
  • Museum
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    Lossi 25, 51014, Tartu
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Support Units
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    Teatri väljak 3, 10143 Tallinn
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    Ülikooli 18a, 51014, Tartu
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    Jakobi 4, 51014, Tartu
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    Faculty address: 
    Ülikooli 18a, 51014, Tartu
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    Ülikooli 17-114, 51014, Tartu
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    Faculty address: 
    Ülikooli 18, ruum 210, 50090, Tartu
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    Ülikooli 18, 50090, Tartu
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    Faculty address: 
    Lossi 3, III korrus, 51003, Tartu
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    Ülikooli 18, rooms 302 and 304, 50090, Tartu
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Other Units
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    W. Struve 1, 50091 Tartu
  • Tartu University Hospital
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  • University of Tartu Foundation
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    Ülikooli 18, 50090 Tartu
  • View all other units

Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
(+372) 737 5341
Faculty address: 
Jakobi 2 - 116-121, 51014, Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116 - 121, 51014, Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    (+372) 737 5651
    Faculty address: 
    Jakobi 2, 51003, Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    (+372) 737 5221
    Faculty address: 
    Jakobi 2, 51014, Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    (+372) 737 5314
    Faculty address: 
    Jakobi 2, III, rooms 309-352, 51014, Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003, Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    (+372) 737 5301
    Faculty address: 
    Ülikooli 18-310, 50090, Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    Lossi 3, 51003, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    (+372) 435 5232
    Faculty address: 
    Posti 1, 71004, Viljandi
Faculty of Social Sciences
Faculty phone: 
(+372) 737 5957
Faculty address: 
Lossi 36, 51003, Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003, Tartu
  • Institute of Education
    Faculty phone: 
    (+372) 737 6440
    Faculty address: 
    Salme 1a, room 29, 50103, Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    (+372) 737 5582
    Faculty address: 
    Lossi 36, roomm 301, 51003, Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    (+372) 737 6310
    Faculty address: 
    J. Liivi 4, 50409, Tartu
  • Institute of Psychology
    Faculty phone: 
    (+372) 737 5902
    Faculty address: 
    Näituse 2, 50409, Tartu
  • School of Law
    Faculty phone: 
    (+372) 737 5390
    Faculty address: 
    Näituse 20, 50409, Tartu
  • Institute of Social Studies
    Faculty phone: 
    (+372) 737 5188
    Faculty address: 
    Lossi 36, 51003, Tartu
  • Narva College
    Faculty phone: 
    (+372) 740 1900
    Faculty address: 
    Raekoja plats 2, 20307, Narva
  • Pärnu College
    Faculty phone: 
    (+372) 445 0520
    Faculty address: 
    Ringi 35, 80012, Pärnu
Faculty of Medicine
Faculty phone: 
(+372) 737 5326
Faculty address: 
Ravila 19, 50411, Tartu
  • Dean's Office
    Faculty phone: 
    (+372) 737 5326
    Faculty address: 
    Ravila 19, 50411, Tartu
  • Institute of Biomedicine and Translational Medicine
    Faculty phone: 
    +(372) 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411, Tartu
  • Institute of Pharmacy
    Faculty phone: 
    (+372) 737 5286
    Faculty address: 
    Nooruse 1, 50411, Tartu
  • Institute of Dentistry
    Faculty phone: 
    (+372) 731 9856
    Faculty address: 
    Raekoja plats 6, 51003, Tartu
  • Institute of Clinical Medicine
    Faculty phone: 
    (+372) 737 5323
    Faculty address: 
    L. Puusepa 8, 51014, Tartu, Eesti
  • Institute of Family Medicine and Public Health
    Faculty phone: 
    (+372) 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    (+372) 737 5360
    Faculty address: 
    Jakobi 5-205, 51014, Tartu
Faculty of Science and Technology
Faculty phone: 
(+372) 737 5820
Faculty address: 
Vanemuise 46-208, 51014, Tartu
  • Dean's Office
    Faculty phone: 
    (+372) 737 5820
    Faculty address: 
    Vanemuise 46 - 208, 51014, Tartu
  • Institute of Computer Science
    Faculty phone: 
    (+372) 737 5445
    Faculty address: 
    J. Liivi 2, 50409, Tartu
  • Estonian Marine Institute
    Faculty phone: 
    (+372) 671 8902
    Faculty address: 
    Mäealuse 14, 12618, Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi Str 1, 50411, Tartu
  • Institute of Chemistry
    Faculty phone: 
    (+372) 737 5261
    Faculty address: 
    Ravila 14a, 50411, Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    (+372) 737 5860
    Faculty address: 
    J. Liivi 2, 50409, Tartu
  • Institute of Molecular and Cell Biology
    Faculty phone: 
    (+372) 737 5011
    Faculty address: 
    Riia 23, 23b-134, 51010, Tartu
  • Institute of Technology
    Faculty phone: 
    (+372) 737 4800
    Faculty address: 
    Nooruse 1, 50411, Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    (+372) 737 5835
    Faculty address: 
    Vanemuise 46, 51014, Tartu
Institutions
  • Library
    Faculty phone: 
    (+372) 737 5702
    Faculty address: 
    W.Struve 1, 50091, Tartu
  • Youth Academy
    Faculty phone: 
    (+372) 737 5581
    Faculty address: 
    Lossi 38, 51003, Tartu
  • Estonian Genome Center
    Faculty phone: 
    (+372) 737 4000
    Faculty address: 
    Riia 23b, 51010, Tartu
  • Museum
    Faculty phone: 
    (+372) 737 5674
    Faculty address: 
    Lossi 25, 51014, Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    (+372) 737 6076
    Faculty address: 
    Vanemuise 46, 51014, Tartu
Support Units
  • Administrative Office
    Faculty phone: 
    (+372) 737 5606
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    (+372) 737 5137
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • Finance Office
    Faculty phone: 
    (+372) 737 5125
    Faculty address: 
    Jakobi 4, 51014, Tartu
  • Information Technology Office
    Faculty phone: 
    (+372) 737 6000, arvutiabi: 737 5500
    Faculty address: 
    Ülikooli 18a, 51014, Tartu
  • Internal Audit Office
    Faculty address: 
    Ülikooli 17-114, 51014, Tartu
  • Marketing and Communication Office
    Faculty phone: 
    (+372) 737 5687
    Faculty address: 
    Ülikooli 18, ruum 210, 50090, Tartu
  • Office of Academic Affairs
    Faculty phone: 
    (+372) 737 6215
    Faculty address: 
    Ülikooli 18, 50090, Tartu
  • Office of Research and Development
    Faculty phone: 
    (+372) 737 6192
    Faculty address: 
    Lossi 3, III korrus, 51003, Tartu
  • Human Resources Office
    Faculty phone: 
    (+372) 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090, Tartu
  • Rector's Strategy Office
    Faculty phone: 
    (+372) 737 5600
    Faculty address: 
    Ülikooli 18, 51014, Tartu
  • Student Council
    Faculty phone: 
    (+372) 737 5400
    Faculty address: 
    Ülikooli 18b, 51014, Tartu
Other Units
  • University of Tartu Academic Sports Club
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • University of Tartu Press
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Study: new gene variations affecting heart rate to serve as a basis for a better treatment and prevention of heart disease

An international gene study involving more than 180,000 people that was conducted with the help of University of Tartu researchers identified a number of new gene variations affecting the heart rate. The newly found sequence variations and genes improve our understanding of the molecular mechanisms regulating heart function and hopefully lead to the development of new medicinal products for irregular heartbeat. The study also included the data of 5500 gene donors of the Estonian Genome Centre, University of Tartu.

Researchers at the UT Estonian Genome Centre in cooperation with their colleagues from a large multinational consortium studied more than 180,000 people from all over the world to examine the differences in heart rate among people and identified 14 new genome areas that affect it. The study confirmed the connection of seven previously known DNA sequence variations to the heart rate; combined, they increase the heart rate by about five beats per minute. The results of the study help to better understand the molecular background of the heart’s working mechanism, providing options for a better treatment and prevention of heart disease.

In contrast to the standard analyses of patients, the study focused on healthy volunteers with no cardiovascular complications. The researchers examined the effect of the gene variants on the heart rate, which is a well-known risk factor for the development of several kinds of heart disease.

According to Tõnu Esko, one of the lead authors of the study and a research fellow at the UT Estonian Genome Centre, it is no surprise that the effect of the identified DNA sequence variations on the heart rate is not great, while the personal risk assessments based on genetic characteristics are becoming increasingly accurate precisely thanks to such international surveys. The study also assessed the role of the found DNA sequence variations among other parameters characterising heart function and identified a connection with several EKG statistics, while also identifying a heightened risk for the development of irregular heartbeat. “The found genome areas include several promising candidate genes for understanding the molecular mechanisms behind heart rate, and a potential future medicinal product affecting the biological mechanism identified by the study might prove an effective remedy for this disease in the future,” Esko says of the significance of the study.

The researchers conducted gene inactivation experiments on two model organisms, the fruit fly and the zebrafish, and demonstrated the role of at least 20 genes in the regulation of heart rate, the transfer of nerve signal, and the embryonic development of the heart. According to Esko, this shows that the genes identified using statistics and bioinformatics are not just a noise in the data but actually affect the development and function of the heart in different model organisms to a significant degree.

In the course of the study, the data of 181,171 people were analysed; the international cooperation project involved a total of 268 researchers from 211 research institutions and six multinational consortiums.

An article on the recent gene study was published in the journal Nature Genetics on Sunday, 14 April.

Virge Tamme
Press Officer of the UT
Phone: +372 737 5683
Mobile: +372 5815 5392
E-mail: virge.tamme [ät] ut.ee
www.ut.ee