The research project investigates the applicability of new printable pharmaceuticals in the development of personalized (patient-specific) medicines for pediatric and geriatric use. Novel biocompatible thin films that would serve as biodegradable substrates for printable drugs are designed and characterized. The hypothesis is that the present personalized drug-delivery systems using printing technology could replace conventional pharmaceuticals in many therapeutic application areas.
We develop new topical nanomedicines for wound healing (including burn therapy), evaluate biocompatible polymers as carriers in these nanomedicines, and optimize healing efficiency of the nanomedicines carrying active ingredients in suitable in vitro / ex vivo models. Nanopharmaceutical approach to promote wound healing will be made by means of novel multifunctional nanofibrous mats (“all-in-one” wound dressings) and phospholipid-based drug delivery systems (liposomes-in-hydrogel).
Today there is a need and a technological window to design and produce new kinds of non-woven nanostructured materials for e.g. drug delivery systems and tissue engineering. By using a needleless electrospinning (ES) technology, one can fabricate entirely novel non-woven nanomedicines (nanofibers and mats) to specification (fiber shape, inner structure, and chemical gradients). These nanostructures may provide drug delivery systems (e.g.
Physical stability and dissolution properties of drug substances can be modified using an amorphous solid dispersion (ASD) approach and by revealing systematic understanding of solid-state transformations in the presence of excipients. Therefore, the ASD approach may have a significant impact on the improvements in pharmaceutical formulations of poorly water-soluble drugs in the future. The goal of this research work is to develop novel ASDs of poorly water-soluble drug(s) and polymers (HPMC, polydextrose, PVP, chitosan, novel graft copolymer, etc.).
New biomaterials (celluloses, lignin, suberin, betulin, etc.) and synthetic materials (graft copolymer Soluplus, D-gluconic acid lactone, etc.) as novel multifunctional excipients in pharmaceutical solid dosage manufacturing are investigated. These materials are readily available, cheap and co-processable with other pharmaceutical excipients. The strong hypothesis is that the present materials are capable of being used in manufacturing with modern equipments on the pharmaceutical industrial scale, and that the respective finished products are stable during storage.
research on quantum chemistry methods and their applications in describing molecular systems in the gas phase and condensed environments
designing modern technology and software and using them to find quantitative structure/characteristic dependency models, which are then used to predict the characteristics of materials. Applying artificial intellect methods (artificial neural networks etc.) in chemistry and related fields in order to make new discoveries and predict molecular structures of pre-identified characteristics.