[Header]
Format=SMU
ver=3
appl=GUMWB32
MR=0
FUEB=1

[Title]
Title='Assay of Simvastatin in Tablets by HPLC'
Description=18
Description[0]='The measurand: mean Simvastatin content of the set of 8 tablets that were taken'
Description[1]='as the sample.'
Description[2]=''
Description[3]='The prototype of the method is based on the monographs of Simvastatin in the'
Description[4]='European Pharmacopoeia (Ph.Eur. 5th Ed.) and the United States Pharmacopoeia /'
Description[5]='the National Formulary (USP 27 / NF 22).'
Description[6]=''
Description[7]='Scope of use and validation: Quantitative determination of Simvastatin in drug'
Description[8]='products.'
Description[9]=''
Description[10]='Principle: The drug substance is extracted from the tablets by using solution'
Description[11]='of the 0.01M phosphate buffer pH4.0 and acetonitrile in the ratio 20:80 (V/V).'
Description[12]='The samples are filtered and the resulting solution is injected into HPLC.'
Description[13]='Separation is achieved at room temperature in a Phenomenex Prodigy 3 u ODS'
Description[14]='(end-capped) column (30 x 4.60 mm), detection wavelength is 238 nm. A Single'
Description[15]='standard solution or a series of calibration solutions (depending on the'
Description[16]='calibration procedure) of Simvastatin standard substance is used for'
Description[17]='calibration.'

[Model]
Model=101
Model[0]='{ The main equation'
Model[1]='      Calibration graph method (with slope b_1 and intercept b_0) is used for quantitation'
Model[2]='      The result is given Recovery-corrected (R)'
Model[3]='      The sample solution is prepared by dissolving several tablets to achieve averaging'
Model[4]='}'
Model[5]=''
Model[6]='C_SVT = (A_sample - b_0) *  V_100 / ( b_1 *  n_tab * R);'
Model[7]=''
Model[8]=''
Model[9]=''
Model[10]='{ Chromatographic measurements'
Model[11]='Peak areas are used as the basis for quantification.'
Model[12]='We assume that the uncertainty of the chromatographic peak area of the sample solution has 4 components'
Model[13]='         - Repeatability (contained in A_sample\us\rep)'
Model[14]='         - Uncertainty due to detector drift (A_sample\us\drift)'
Model[15]='         - Uncertainty due to imperfection of peak integration (A_sample\us\integr)'
Model[16]='         - Uncertainty due to the slight nonlinearity of the calibration graph (A_sample\us\nonlin)'
Model[17]='The A_sample\us\rep carries the value and the repeatability uncertainty. The other components carry the respective uncertainty component only, their value is 0.'
Model[18]='}'
Model[19]=''
Model[20]='{ Sample peak area }'
Model[21]=''
Model[22]='A_sample = A_sample\us\rep + A_sample\us\drift + A_sample\us\integr + A_sample\us\nonlin;'
Model[23]=''
Model[24]=''
Model[25]='{ Recovery'
Model[26]='     The value of Recovery (R_0) has been determined from spiking studies.'
Model[27]='     The R_0 also contains the sample-to-sample variability uncertainty component'
Model[28]='     The A_R\us\eff is the effective peak area during recovery determination and it takes into account the uncertainty in determining the recovery value.'
Model[29]='     The division by the const() function reforms A_R\us\eff into a coefficient with vaule 1 and uncertainty equal to the relative uncertainty of A_R\us\eff.'
Model[30]='}'
Model[31]=''
Model[32]='R = R_0 * A_R\us\eff / const(A_R\us\eff);'
Model[33]='A_R\us\eff = A_R\us\eff\us\integr + A_R\us\eff\us\nonlin;'
Model[34]=''
Model[35]=''
Model[36]='{ Peak areas of the calibration standard solutions'
Model[37]='   Their areas have the same components as the sample peak area, except that the nonlinearity uncertainty contribution is not included.'
Model[38]='}'
Model[39]=''
Model[40]='A_1 = A_1rep + A_1drift + A_1integr;'
Model[41]='A_2 = A_2rep + A_2drift + A_2integr;'
Model[42]='A_3 = A_3rep + A_3drift + A_3integr;'
Model[43]='A_4 = A_4rep + A_4drift + A_4integr;'
Model[44]='A_5 = A_5rep + A_5drift + A_5integr;'
Model[45]=''
Model[46]=''
Model[47]=''
Model[48]='{ Linear regression equations (Calibration graph is used for quantitation) }'
Model[49]=''
Model[50]='\Sigma\AC = C_1*A_1 + C_2*A_2 + C_3*A_3 +C_4*A_4 + C_5*A_5;'
Model[51]='AvgC=(C_1+C_2+C_3+C_4+C_5)/n;'
Model[52]='AvgA=(A_1+A_2+A_3+A_4+A_5)/n;'
Model[53]='\Sigma\CC=C_1*C_1+C_2*C_2+C_3*C_3+C_4*C_4+C_5*C_5;'
Model[54]='b_1=(\Sigma\AC-n*AvgC*AvgA)/(\Sigma\CC-n*AvgC*AvgC);'
Model[55]='b_0=AvgA-b_1*AvgC;'
Model[56]=''
Model[57]=''
Model[58]='{ Preparation of standard solutions }'
Model[59]=''
Model[60]='C_1 = m_1 * P_std / (V_1\us\50 * 100);'
Model[61]='C_2 = m_2 * P_std / (V_2\us\50 * 100);'
Model[62]='C_3 = m_3 * P_std / (V_3\us\50 * 100);'
Model[63]='C_4 = m_4 * P_std / (V_4\us\50 * 100);'
Model[64]='C_5 = m_5 * P_std / (V_5\us\50 * 100);'
Model[65]=''
Model[66]=''
Model[67]='{ Uncertainity of weighing'
Model[68]='}'
Model[69]=''
Model[70]='m_1 = m_1\us\rep + m_1\us\buoyancy + m_1\us\drift + m_1\us\round + m_1\us\electrost;'
Model[71]='m_2 = m_2\us\rep + m_2\us\buoyancy + m_2\us\drift + m_2\us\round + m_2\us\electrost;'
Model[72]='m_3 = m_3\us\rep + m_3\us\buoyancy + m_3\us\drift + m_3\us\round + m_3\us\electrost;'
Model[73]='m_4 = m_4\us\rep + m_4\us\buoyancy + m_4\us\drift + m_4\us\round + m_4\us\electrost;'
Model[74]='m_5 = m_5\us\rep + m_5\us\buoyancy + m_5\us\drift + m_5\us\round + m_5\us\electrost;'
Model[75]=''
Model[76]='m_1\us\buoyancy = m_1\us\rep * f_buoyancy;'
Model[77]='m_2\us\buoyancy = m_2\us\rep * f_buoyancy;'
Model[78]='m_3\us\buoyancy = m_3\us\rep * f_buoyancy;'
Model[79]='m_4\us\buoyancy = m_4\us\rep * f_buoyancy;'
Model[80]='m_5\us\buoyancy = m_5\us\rep * f_buoyancy;'
Model[81]=''
Model[82]=''
Model[83]='{ Volumes of 50 ml volumetric flask }'
Model[84]=''
Model[85]='V_1\us\50 = V_1\us\50\us\cal + V_1\us\50\us\fill + V_1\us\50\us\temp;'
Model[86]='V_2\us\50 = V_2\us\50\us\cal + V_2\us\50\us\fill + V_2\us\50\us\temp;'
Model[87]='V_3\us\50 = V_3\us\50\us\cal + V_3\us\50\us\fill + V_3\us\50\us\temp;'
Model[88]='V_4\us\50 = V_4\us\50\us\cal + V_4\us\50\us\fill + V_4\us\50\us\temp;'
Model[89]='V_5\us\50 = V_5\us\50\us\cal + V_5\us\50\us\fill + V_5\us\50\us\temp;'
Model[90]='V_1\us\50\us\temp = V_1\us\50\us\cal * \Delta\t * \gamma\_w;'
Model[91]='V_2\us\50\us\temp = V_2\us\50\us\cal * \Delta\t * \gamma\_w;'
Model[92]='V_3\us\50\us\temp = V_3\us\50\us\cal * \Delta\t * \gamma\_w;'
Model[93]='V_4\us\50\us\temp = V_4\us\50\us\cal * \Delta\t * \gamma\_w;'
Model[94]='V_5\us\50\us\temp = V_5\us\50\us\cal * \Delta\t * \gamma\_w;'
Model[95]=''
Model[96]=''
Model[97]='{ Volume of the sample solution }'
Model[98]=''
Model[99]='V_100 = V_100\us\cal + V_100\us\fill + V_100\us\temp;'
Model[100]='V_100\us\temp = V_100\us\cal * \Delta\t * \gamma\_w;'
CE=1
CTC=1

[Components]
CompOrder=1
Comp=102
Comp[0]=A_1_
Comp[1]=A_1drift_
Comp[2]=A_1integr_
Comp[3]=A_1rep_
Comp[4]=A_2_
Comp[5]=A_2drift_
Comp[6]=A_2integr_
Comp[7]=A_2rep_
Comp[8]=A_3_
Comp[9]=A_3drift_
Comp[10]=A_3integr_
Comp[11]=A_3rep_
Comp[12]=A_4_
Comp[13]=A_4drift_
Comp[14]=A_4integr_
Comp[15]=A_4rep_
Comp[16]=A_5_
Comp[17]=A_5drift_
Comp[18]=A_5integr_
Comp[19]=A_5rep_
Comp[20]=A_R\us\eff_
Comp[21]=A_R\us\eff\us\integr_
Comp[22]=A_R\us\eff\us\nonlin_
Comp[23]=A_sample_
Comp[24]=A_sample\us\drift_
Comp[25]=A_sample\us\integr_
Comp[26]=A_sample\us\nonlin_
Comp[27]=A_sample\us\rep_
Comp[28]=AvgA
Comp[29]=AvgC
Comp[30]=b_0_
Comp[31]=b_1_
Comp[32]=C_1_
Comp[33]=C_2_
Comp[34]=C_3_
Comp[35]=C_4_
Comp[36]=C_5_
Comp[37]=C_SVT_
Comp[38]=f_buoyancy_
Comp[39]=m_1_
Comp[40]=m_1\us\buoyancy_
Comp[41]=m_1\us\drift_
Comp[42]=m_1\us\electrost_
Comp[43]=m_1\us\rep_
Comp[44]=m_1\us\round_
Comp[45]=m_2_
Comp[46]=m_2\us\buoyancy_
Comp[47]=m_2\us\drift_
Comp[48]=m_2\us\electrost_
Comp[49]=m_2\us\rep_
Comp[50]=m_2\us\round_
Comp[51]=m_3_
Comp[52]=m_3\us\buoyancy_
Comp[53]=m_3\us\drift_
Comp[54]=m_3\us\electrost_
Comp[55]=m_3\us\rep_
Comp[56]=m_3\us\round_
Comp[57]=m_4_
Comp[58]=m_4\us\buoyancy_
Comp[59]=m_4\us\drift_
Comp[60]=m_4\us\electrost_
Comp[61]=m_4\us\rep_
Comp[62]=m_4\us\round_
Comp[63]=m_5_
Comp[64]=m_5\us\buoyancy_
Comp[65]=m_5\us\drift_
Comp[66]=m_5\us\electrost_
Comp[67]=m_5\us\rep_
Comp[68]=m_5\us\round_
Comp[69]=n
Comp[70]=n_tab_
Comp[71]=P_std_
Comp[72]=R
Comp[73]=R_0_
Comp[74]=V_100_
Comp[75]=V_100\us\cal_
Comp[76]=V_100\us\fill_
Comp[77]=V_100\us\temp_
Comp[78]=V_1\us\50_
Comp[79]=V_1\us\50\us\cal_
Comp[80]=V_1\us\50\us\fill_
Comp[81]=V_1\us\50\us\temp_
Comp[82]=V_2\us\50_
Comp[83]=V_2\us\50\us\cal_
Comp[84]=V_2\us\50\us\fill_
Comp[85]=V_2\us\50\us\temp_
Comp[86]=V_3\us\50_
Comp[87]=V_3\us\50\us\cal_
Comp[88]=V_3\us\50\us\fill_
Comp[89]=V_3\us\50\us\temp_
Comp[90]=V_4\us\50_
Comp[91]=V_4\us\50\us\cal_
Comp[92]=V_4\us\50\us\fill_
Comp[93]=V_4\us\50\us\temp_
Comp[94]=V_5\us\50_
Comp[95]=V_5\us\50\us\cal_
Comp[96]=V_5\us\50\us\fill_
Comp[97]=V_5\us\50\us\temp_
Comp[98]=\Delta\t
Comp[99]=\gamma\_w_
Comp[100]=\Sigma\AC
Comp[101]=\Sigma\CC

[COMP 0]
Type=Temp
Definition='Peak area of the 1. calibration standard solution'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=4407267
Ustd=21071.3075057055
Neff=114
HB=1
HC=0
HR=1
IO=0

[COMP 1]
Type=TypBRectang
Definition='Drift uncertainty component of the peak area of the 1. calibration standard solution'
Unit='AU'
Description=4
Description[0]='The drift per hour is maximum 12 000 peak area units. Assuming that the'
Description[1]='solution will be kept no longer than 2 hours between preparation and'
Description[2]='measurement we arrive at this uncertainty estimate. This uncertainty estimate'
Description[3]='is essentially independent of the peak area.'
Vnom=0
Hlim=24000

[COMP 2]
Type=TypBRectang
Definition='Integration uncertainty component of the peak area of the 1. calibration standard solution'
Unit='AU'
Description=5
Description[0]='This uncertainty contribution has been obtained by integrating the peak in two'
Description[1]='ways - one somewhat underestimating (Area(min)) and the other somewhat'
Description[2]='overestimating (Area(max)) the peak area. The uncertainty contribution has been'
Description[3]='taken equal to [Area(max)-Area(min)]/2. See text for more detail. According to'
Description[4]='our data this uncertainty contribution is proportional to the peak area.'
Vnom=0
Hlim=18000

[COMP 3]
Type=TypASum
Definition='Value and the repeatability uncertainty component of the peak area of the 1. calibration standard solution'
Unit='AU'
Description=5
Description[0]='The repeatability uncertainty has been estimated using the pooled standard'
Description[1]='deviation of triplicate injections (altogether 3 x 6 injections) of a standard'
Description[2]='solution subjected to different stability tests. See the text for more detail.'
Description[3]='According to our data this uncertainty contribution is essentially independent'
Description[4]='of the sample peak area.'
Vnom=4407267
Ustd=12000
Neff=12

[COMP 4]
Type=Temp
Definition='Peak area of the 2. calibration standard solution'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=6436226
Ustd=28936.7125522809
Neff=405
HB=1
HC=0
HR=1
IO=0

[COMP 5]
Type=TypBRectang
Definition='Drift uncertainty component of the peak area of the 2. calibration standard solution'
Unit='AU'
Description=4
Description[0]='The drift per hour is maximum 12 000 peak area units. Assuming that the'
Description[1]='solution will be kept no longer than 3 hours between preparation and'
Description[2]='measurement we arrive at this uncertainty estimate. This uncertainty estimate'
Description[3]='is essentially independent of the peak area.'
Vnom=0
Hlim=36000

[COMP 6]
Type=TypBRectang
Definition='Integration uncertainty component of the peak area of the 2. calibration standard solution'
Unit='AU'
Description=5
Description[0]='This uncertainty contribution has been obtained by integrating the peak in two'
Description[1]='ways - one somewhat underestimating (Area(min)) and the other somewhat'
Description[2]='overestimating (Area(max)) the peak area. The uncertainty contribution has been'
Description[3]='taken equal to [Area(max)-Area(min)]/2. See text for more detail. According to'
Description[4]='our data this uncertainty contribution is proportional to the peak area.'
Vnom=0
Hlim=28000

[COMP 7]
Type=TypASum
Definition='Value and the repeatability uncertainty component of the peak area of the 2. calibration standard solution'
Unit='AU'
Description=5
Description[0]='The repeatability uncertainty has been estimated using the pooled standard'
Description[1]='deviation of triplicate injections (altogether 3 x 6 injections) of a standard'
Description[2]='solution subjected to different stability tests. See the text for more detail.'
Description[3]='According to our data this uncertainty contribution is essentially independent'
Description[4]='of the sample peak area.'
Vnom=6436226
Ustd=12000
Neff=12

[COMP 8]
Type=Temp
Definition='Peak area of the 3. calibration standard solution'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=8987202
Ustd=37497.7777119303
Neff=1144
HB=1
HC=0
HR=1
IO=0

[COMP 9]
Type=TypBRectang
Definition='Drift uncertainty component of the peak area of the 3. calibration standard solution'
Unit='AU'
Description=4
Description[0]='The drift per hour is maximum 12 000 peak area units. Assuming that the'
Description[1]='solution will be kept no longer than 4 hours between preparation and'
Description[2]='measurement we arrive at this uncertainty estimate. This uncertainty estimate'
Description[3]='is essentially independent of the peak area.'
Vnom=0
Hlim=48000

[COMP 10]
Type=TypBRectang
Definition='Integration uncertainty component of the peak area of the 3. calibration standard solution'
Unit='AU'
Description=5
Description[0]='This uncertainty contribution has been obtained by integrating the peak in two'
Description[1]='ways - one somewhat underestimating (Area(min)) and the other somewhat'
Description[2]='overestimating (Area(max)) the peak area. The uncertainty contribution has been'
Description[3]='taken equal to [Area(max)-Area(min)]/2. See text for more detail. According to'
Description[4]='our data this uncertainty contribution is proportional to the peak area.'
Vnom=0
Hlim=38500

[COMP 11]
Type=TypASum
Definition='Value and the repeatability uncertainty component of the peak area of the 3. calibration standard solution'
Unit='AU'
Description=5
Description[0]='The repeatability uncertainty has been estimated using the pooled standard'
Description[1]='deviation of triplicate injections (altogether 3 x 6 injections) of a standard'
Description[2]='solution subjected to different stability tests. See the text for more detail.'
Description[3]='According to our data this uncertainty contribution is essentially independent'
Description[4]='of the sample peak area.'
Vnom=8987202
Ustd=12000
Neff=12

[COMP 12]
Type=Temp
Definition='Peak area of the 4. calibration standard solution'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=10642449.5
Ustd=45610.6712659804
Neff=2504
HB=1
HC=0
HR=1
IO=0

[COMP 13]
Type=TypBRectang
Definition='Drift uncertainty component of the peak area of the 4. calibration standard solution'
Unit='AU'
Description=4
Description[0]='The drift per hour is maximum 12 000 peak area units. Assuming that the'
Description[1]='solution will be kept no longer than 5 hours between preparation and'
Description[2]='measurement we arrive at this uncertainty estimate. This uncertainty estimate'
Description[3]='is essentially independent of the peak area.'
Vnom=0
Hlim=60000

[COMP 14]
Type=TypBRectang
Definition='Integration uncertainty component of the peak area of the 4. calibration standard solution'
Unit='AU'
Description=5
Description[0]='This uncertainty contribution has been obtained by integrating the peak in two'
Description[1]='ways - one somewhat underestimating (Area(min)) and the other somewhat'
Description[2]='overestimating (Area(max)) the peak area. The uncertainty contribution has been'
Description[3]='taken equal to [Area(max)-Area(min)]/2. See text for more detail. According to'
Description[4]='our data this uncertainty contribution is proportional to the peak area.'
Vnom=0
Hlim=47000

[COMP 15]
Type=TypASum
Definition='Value and the repeatability uncertainty component of the peak area of the 4. calibration standard solution'
Unit='AU'
Description=5
Description[0]='The repeatability uncertainty has been estimated using the pooled standard'
Description[1]='deviation of triplicate injections (altogether 3 x 6 injections) of a standard'
Description[2]='solution subjected to different stability tests. See the text for more detail.'
Description[3]='According to our data this uncertainty contribution is essentially independent'
Description[4]='of the sample peak area.'
Vnom=10642449.5
Ustd=12000
Neff=12

[COMP 16]
Type=Temp
Definition='Peak area of the 5. calibration standard solution'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=13070522
Ustd=54535.1568562275
Neff=5118
HB=1
HC=0
HR=1
IO=0

[COMP 17]
Type=TypBRectang
Definition='Drift uncertainty component of the peak area of the 5. calibration standard solution'
Unit='AU'
Description=4
Description[0]='The drift per hour is maximum 12 000 peak area units. Assuming that the'
Description[1]='solution will be kept no longer than 6 hours between preparation and'
Description[2]='measurement we arrive at this uncertainty estimate. This uncertainty estimate'
Description[3]='is essentially independent of the peak area.'
Vnom=0
Hlim=72000

[COMP 18]
Type=TypBRectang
Definition='Integration uncertainty component of the peak area of the 5. calibration standard solution'
Unit='AU'
Description=5
Description[0]='This uncertainty contribution has been obtained by integrating the peak in two'
Description[1]='ways - one somewhat underestimating (Area(min)) and the other somewhat'
Description[2]='overestimating (Area(max)) the peak area. The uncertainty contribution has been'
Description[3]='taken equal to [Area(max)-Area(min)]/2. See text for more detail. According to'
Description[4]='our data this uncertainty contribution is proportional to the peak area.'
Vnom=0
Hlim=57500

[COMP 19]
Type=TypASum
Definition='Value and the repeatability uncertainty component of the peak area of the 5. calibration standard solution'
Unit='AU'
Description=5
Description[0]='The repeatability uncertainty has been estimated using the pooled standard'
Description[1]='deviation of triplicate injections (altogether 3 x 6 injections) of a standard'
Description[2]='solution subjected to different stability tests. See the text for more detail.'
Description[3]='According to our data this uncertainty contribution is essentially independent'
Description[4]='of the sample peak area.'
Vnom=13070522
Ustd=12000
Neff=12

[COMP 20]
Type=Temp
Definition='The effective peak area during the Recovery determination (difference of the peak areas of spiked and unspiked solutions)'
Unit='AU'
Description=7
Description[0]='The systemati influences are practically limited to the systematic effects in'
Description[1]='peak areas (repeatability can thus be excluded). Also, it is necessary to keep'
Description[2]='in mind that calculation of Recovery by spiking experiments leads to'
Description[3]='differences of areas of peaks that have been obtained within short time'
Description[4]='intervals (the drift component can thus be excluded). Therefore the components'
Description[5]='to be included are the integration uncertainty and the uncertainty due to'
Description[6]='nonlinearity.'
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=3000000
Ustd=24212.6688601925
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 21]
Type=TypBRectang
Definition='The value and integration uncertainty of the effective peak area during the recovery determination'
Unit='AU'
Description=0
Vnom=3000000
Hlim=12600

[COMP 22]
Type=TypBRectang
Definition='The uncertainty of the effective peak area due to nonlinearity of the calibration graph during the recovery determination'
Unit='AU'
Description=0
Vnom=0
Hlim=40000

[COMP 23]
Type=Temp
Definition='Peak area of the sample solution'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=8349089
Ustd=50026.6595593456
Neff=1345
HB=0
HC=0
HR=0
IO=0

[COMP 24]
Type=TypBRectang
Definition='Drift uncertainty component of the sample peak area'
Unit='AU'
Description=4
Description[0]='The drift per hour is maximum 12 000 peak area units. Assuming that the sample'
Description[1]='solution will be kept no longer than 5 hours between preparation and'
Description[2]='measurement we arrive at this uncertainty estimate. This uncertainty estimate'
Description[3]='is essentially independent of the peak area.'
Vnom=0
Hlim=60000

[COMP 25]
Type=TypBRectang
Definition='Integration uncertainty component of the sample peak area'
Unit='AU'
Description=5
Description[0]='This uncertainty contribution has been obtained by integrating the peak in two'
Description[1]='ways - one somewhat underestimating (Area(min)) and the other somewhat'
Description[2]='overestimating (Area(max)) the peak area. The uncertainty contribution has been'
Description[3]='taken equal to [Area(max)-Area(min)]/2. See text for more detail. According to'
Description[4]='our data this uncertainty contribution is proportional to the peak area.'
Vnom=0
Hlim=35000

[COMP 26]
Type=TypBRectang
Definition='Uncertainty component of the sample peak area that takes into account the slight non-linearity of the calibration graph'
Unit='AU'
Description=7
Description[0]='This uncertainty contribution has been estimated from the behavior of the'
Description[1]='residuals of the calibration line. The uncertainty corresponds to the maximum'
Description[2]='possible devaition (in terms of peak area) of the calibration line from the'
Description[3]='actual concentration vs peak area relationship. This uncertainty contribution'
Description[4]='is assigned only to the peak area of the sample and not to the peak areas of'
Description[5]='the standard solutions. According to this approach this uncertainty'
Description[6]='countribution is assumed to be independent of the peak area of the sample.'
Vnom=0
Hlim=40000

[COMP 27]
Type=TypASum
Definition='The value of the sample solution peak area together with its repeatability uncertainty'
Unit='AU'
Description=5
Description[0]='The repeatability uncertainty has been estimated using the pooled standard'
Description[1]='deviation of triplicate injections (altogether 3 x 14 injections) of a sample'
Description[2]='solution subjected to different stability tests. See the text for more detail.'
Description[3]='According to our data this uncertainty contribution is essentially independent'
Description[4]='of the sample peak area.'
Vnom=8349089
Ustd=19000
Neff=28

[COMP 28]
Type=Temp
Definition='Interim quantity for regression statistics calculation'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=8708733.3
Ustd=28032.7189786031
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 29]
Type=Temp
Definition='Interim quantity for regression statistics calculation'
Unit='mg/ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0.80900972152
Ustd=0.00361080973943389
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 30]
Type=Temp
Definition='Intercept of the calibration line'
Unit='AU'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=145855.3410348
Ustd=38325.133299416
Neff=999
HB=0
HC=0
HR=0
IO=0

[COMP 31]
Type=Temp
Definition='Slope of the calibration line'
Unit='AU*ml/mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=10584394.3913021
Ustd=77774.2352067926
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 32]
Type=Temp
Definition='Concentration of the 1. calibration standard solution'
Unit='mg/ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0.4063555496
Ustd=0.0019529750173156
Neff=7358
HB=0
HC=0
HR=0
IO=0

[COMP 33]
Type=Temp
Definition='Concentration of the 2. calibration standard solution'
Unit='mg/ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0.5914244336
Ustd=0.00283505242291524
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 34]
Type=Temp
Definition='Concentration of the 3. calibration standard solution'
Unit='mg/ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0.8322129816
Ustd=0.00395807686561459
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 35]
Type=Temp
Definition='Concentration of the 4. calibration standard solution'
Unit='mg/ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0.9916110204
Ustd=0.004706051782186
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 36]
Type=Temp
Definition='Concentration of the 5. calibration standard solution'
Unit='mg/ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=1.2234446224
Ustd=0.00580852379478739
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 37]
Type=Result
Definition='Content of simvastatin in Simvastatin 10 mg tablets'
Unit='mg/tab'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=9.66789416434567
Ustd=0.11376993463709
Neff=1296
HB=1
HC=0
HR=1
IO=0

[COMP 38]
Type=TypBRectang
Definition='Correction factor for air buoyancy'
Unit='unitless'
Description=4
Vnom=0.0010
Hlim=0.0002
Description[0]='The buoyancy factor is the part (around one thousandth under our conditions) of'
Description[1]='the mass that is added to the balance reading in order to get the physical mass'
Description[2]='of the weighed substance. The uncertainty estimate is deliberately very'
Description[3]='conservative.'

[COMP 39]
Type=Temp
Definition='Mass of the Simvastatin CRS taken for preparation of the 1. calibration standard solution'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=20.44042
Ustd=0.0618566492477567
Neff=1156
HB=0
HC=0
HR=0
IO=0

[COMP 40]
Type=Temp
Definition='Air buoyancy component of uncertainity of mass m1'
Unit='mg'
Description=0
Vnom=0.02042
Ustd=0.00235797996033328
Neff=10000
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
HB=0
HC=0
HR=0
IO=0

[COMP 41]
Type=TypASum
Definition='Drift component of uncertainity of mass m1'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=0
Ustd=0.0097
Neff=2
HB=0
HC=0
HR=0
IO=0

[COMP 42]
Type=TypBRectang
Definition='Electrostatic component of uncertainity of mass m1'
Unit='mg'
Description=4
Vnom=0
Ustd=0.0097
Neff=2
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Hlim=0.10

[COMP 43]
Type=TypASum
Definition='Value of the mass of the Simvastatin CRS taken for preparation of the 1. calibration standard solution together with repeatability component of uncertainity'
Unit='mg'
Description=0
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Vnom=20.42
Hlim=0.10
Ustd=0.0196
Neff=18

[COMP 44]
Type=TypBRectang
Definition='Rounding component of uncertainity of mass m1'
Unit='mg'
Description=0
Vnom=0
Hlim=0.005

[COMP 45]
Type=Temp
Definition='Mass of the Simvastatine CRS taken for preparation of the 2. calibration standard solution'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=29.74972
Ustd=0.0894378503924746
Neff=5054
HB=0
HC=0
HR=0
IO=0

[COMP 46]
Type=Temp
Definition='Air buoyancy component of uncertainity of mass m2'
Unit='mg'
Description=0
Vnom=0.02972
Ustd=0.00343182597072365
Neff=10000
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
HB=0
HC=0
HR=0
IO=0

[COMP 47]
Type=TypASum
Definition='Drift component of uncertainity of mass m2'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=0
Ustd=0.0097
Neff=2
HB=0
HC=0
HR=0
IO=0

[COMP 48]
Type=TypBRectang
Definition='Electrostatic component of uncertainity of mass m2'
Unit='mg'
Description=4
Vnom=0
Ustd=0.0097
Neff=2
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Hlim=0.15

[COMP 49]
Type=TypASum
Definition='Value of the mass of the Simvastatine CRS taken for preparation of the 2. calibration standard solution together with repeatability component of uncertainity'
Unit='mg'
Description=0
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Vnom=29.72
Hlim=0.15
Ustd=0.0196
Neff=18

[COMP 50]
Type=TypBRectang
Definition='Rounding component of uncertainity of mass m2'
Unit='mg'
Description=0
Vnom=0
Hlim=0.005

[COMP 51]
Type=Temp
Definition='Mass of the Simvastatine CRS taken for preparation of the 3. calibration standard solution'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=41.86182
Ustd=0.123331548557104
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 52]
Type=Temp
Definition='Air buoyancy component of uncertainity of mass m3'
Unit='mg'
Description=0
Vnom=0.04182
Ustd=0.00482899742803825
Neff=10000
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
HB=0
HC=0
HR=0
IO=0

[COMP 53]
Type=TypASum
Definition='Drift component of uncertainity of mass m3'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=0
Ustd=0.0097
Neff=2
HB=0
HC=0
HR=0
IO=0

[COMP 54]
Type=TypBRectang
Definition='Electrostatic component of uncertainity of mass m3'
Unit='mg'
Description=4
Vnom=0
Ustd=0.0097
Neff=2
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Hlim=0.21

[COMP 55]
Type=TypASum
Definition='Value of the mass of the Simvastatine CRS taken for preparation of the 3. calibration standard solution together with repeatability component of uncertainity'
Unit='mg'
Description=0
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Vnom=41.82
Hlim=0.21
Ustd=0.0196
Neff=18

[COMP 56]
Type=TypBRectang
Definition='Rounding component of uncertainity of mass m3'
Unit='mg'
Description=0
Vnom=0
Hlim=0.005

[COMP 57]
Type=Temp
Definition='Mass of the Simvastatine CRS taken for preparation of the 4. calibration standard solution'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=49.87983
Ustd=0.146129368789531
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 58]
Type=Temp
Definition='Air buoyancy component of uncertainity of mass m4'
Unit='mg'
Description=0
Vnom=0.04983
Ustd=0.00575390616538018
Neff=10000
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
HB=0
HC=0
HR=0
IO=0

[COMP 59]
Type=TypASum
Definition='Drift component of uncertainity of mass m4'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=0
Ustd=0.0097
Neff=2
HB=0
HC=0
HR=0
IO=0

[COMP 60]
Type=TypBRectang
Definition='Electrostatic component of uncertainity of mass m4'
Unit='mg'
Description=4
Vnom=0
Ustd=0.0097
Neff=2
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Hlim=0.25

[COMP 61]
Type=TypASum
Definition='Value of the mass of the Simvastatine CRS taken for preparation of the 4. calibration standard solution together with repeatability component of uncertainity'
Unit='mg'
Description=0
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Vnom=49.83
Hlim=0.25
Ustd=0.0196
Neff=18

[COMP 62]
Type=TypBRectang
Definition='Rounding component of uncertainity of mass m4'
Unit='mg'
Description=0
Vnom=0
Hlim=0.005

[COMP 63]
Type=Temp
Definition='Mass of the Simvastatine CRS taken for preparation of the 5. calibration standard solution'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=61.54148
Ustd=0.180474603687499
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 64]
Type=Temp
Definition='Air buoyancy component of uncertainity of mass m5'
Unit='mg'
Description=0
Vnom=0.06148
Ustd=0.00709912596685911
Neff=10000
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
HB=0
HC=0
HR=0
IO=0

[COMP 65]
Type=TypASum
Definition='Drift component of uncertainity of mass m5'
Unit='mg'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=0
Ustd=0.0097
Neff=2
HB=0
HC=0
HR=0
IO=0

[COMP 66]
Type=TypBRectang
Definition='Electrostatic component of uncertainity of mass m5'
Unit='mg'
Description=4
Vnom=0
Ustd=0.0097
Neff=2
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Hlim=0.31

[COMP 67]
Type=TypASum
Definition='Value of the mass of the Simvastatine CRS taken for preparation of the 5. calibration standard solution together with repeatability component of uncertainity'
Unit='mg'
Description=0
Description[0]='When weighing the standard substance, intereference from electrostatics'
Description[1]='(instability of the reading) was quite serious and is thus taken into account'
Description[2]='as an uncertainty component. This uncertainty componen has been estimated as'
Description[3]='0.5% of the mass of the substance.'
Vnom=61.48
Hlim=0.31
Ustd=0.0196
Neff=18

[COMP 68]
Type=TypBRectang
Definition='Rounding component of uncertainity of mass m5'
Unit='mg'
Description=0
Vnom=0
Hlim=0.005

[COMP 69]
Type=Const
Definition='Number of points on the calibration line'
Unit='unitless'
Description=0
Vnom=5

[COMP 70]
Type=Const
Definition='Number of the tablets taken for preparation of the sample solution'
Unit='tab'
Description=0
Vnom=8

[COMP 71]
Type=TypBRectang
Definition='Purity of the Simvastatin CRS'
Unit='%'
Description=0
Vnom=99.4
Hlim=0.6

[COMP 72]
Type=Temp
Definition='Recovery'
Unit='unitless'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=1.002068
Ustd=0.00840690066621909
Neff=360
HB=0
HC=0
HR=0
IO=0

[COMP 73]
Type=TypASum
Definition='The value of R and its uncertainty component that is due to the imperfection of the sample preparation procedure'
Unit='unitless'
Description=3
Description[0]='Recovery value and sample-to-sample variability uncertainty. The standard'
Description[1]='uncertainty is the standard deviation of the single mavlue, not the standard'
Description[2]='deviation of the mean'
Vnom=1.002068
Ustd=0.002295
Neff=2

[COMP 74]
Type=Temp
Definition='Volume of the sample solution'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=100
Ustd=0.091571465715764
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 75]
Type=TypBRectang
Definition='Value of the volume of the sample solution together with calibration component of uncertainity'
Unit='ml'
Description=0
Vnom=100.00
Hlim=0.1

[COMP 76]
Type=TypBRectang
Definition='Filling component of uncertainity of volume V_100'
Unit='ml'
Description=0
Vnom=0
Hlim=0.09

[COMP 77]
Type=Temp
Definition='Uncertainity component of volume V_100 due to temperature difference from 20°C'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0
Ustd=0.0484974226119286
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 78]
Type=Temp
Definition='Volume of the 1. calibration standard solution'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=50
Ustd=0.0669925368977769
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 79]
Type=TypBRectang
Definition='Value of the volume of the 1. calibration standard solution together with calibration component of uncertainity'
Unit='ml'
Description=0
Vnom=50.00
Hlim=0.06

[COMP 80]
Type=TypBRectang
Definition='Filling component of uncertainity of volume V_1\us\50'
Unit='ml'
Description=0
Vnom=0
Hlim=0.09

[COMP 81]
Type=Temp
Definition='Uncertainity component of volume V_1\us\50 due to temperature difference from 20°C'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=1
UncID=0
Vnom=0
Ustd=0.0242487113059643
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 82]
Type=Temp
Definition='Volume of the 2. calibration standard solution'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=50
Ustd=0.0669925368977769
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 83]
Type=TypBRectang
Definition='Value of the volume of the 2. calibration standard solution together with calibration component of uncertainity'
Unit='ml'
Description=0
Vnom=50.00
Hlim=0.06

[COMP 84]
Type=TypBRectang
Definition='Filling component of uncertainity of volume V_2\us\50'
Unit='ml'
Description=0
Vnom=0
Hlim=0.09

[COMP 85]
Type=Temp
Definition='Uncertainity component of volume V_2\us\50 due to temperature difference from 20°C'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0
Ustd=0.0242487113059643
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 86]
Type=Temp
Definition='Volume of the 3. calibration standard solution'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=50
Ustd=0.0669925368977769
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 87]
Type=TypBRectang
Definition='Value of the volume of the 3. calibration standard solution together with calibration component of uncertainity'
Unit='ml'
Description=0
Vnom=50.00
Hlim=0.06

[COMP 88]
Type=TypBRectang
Definition='Filling component of uncertainity of volume V_3\us\50'
Unit='ml'
Description=0
Vnom=0
Hlim=0.09

[COMP 89]
Type=Temp
Definition='Uncertainity component of volume V_3\us\50 due to temperature difference from 20°C'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0
Ustd=0.0242487113059643
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 90]
Type=Temp
Definition='Volume of the 4. calibration standard solution'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=50
Ustd=0.0669925368977769
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 91]
Type=TypBRectang
Definition='Value of the volume of the 4. calibration standard solution together with calibration component of uncertainity'
Unit='ml'
Description=0
Vnom=50.00
Hlim=0.06

[COMP 92]
Type=TypBRectang
Definition='Filling component of uncertainity of volume V_4\us\50'
Unit='ml'
Description=0
Vnom=0
Hlim=0.09

[COMP 93]
Type=Temp
Definition='Uncertainity component of volume V_4\us\50 due to temperature difference from 20°C'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0
Ustd=0.0242487113059643
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 94]
Type=Temp
Definition='Volume of the 5. calibration standard solution'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=50
Ustd=0.0669925368977769
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 95]
Type=TypBRectang
Definition='Value of the volume of the 5. calibration standard solution together with calibration component of uncertainity'
Unit='ml'
Description=0
Vnom=50.00
Hlim=0.06

[COMP 96]
Type=TypBRectang
Definition='Filling component of uncertainity of volume V_5\us\50'
Unit='ml'
Description=0
Vnom=0
Hlim=0.09

[COMP 97]
Type=Temp
Definition='Uncertainity component of volume V_5\us\50 due to temperature difference from 20°C'
Unit='ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=0
Ustd=0.0242487113059643
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 98]
Type=TypBRectang
Definition='Diference of solution temperature from 20°C'
Unit='°C'
Description=0
Vnom=0
Hlim=4

[COMP 99]
Type=Const
Definition='Thermal expansion coefficent of water'
Unit='1/°C'
Description=0
Vnom=0.00021

[COMP 100]
Type=Temp
Definition='Interim quantity for regression statistics'
Unit='AU*mg/ml'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=39620954.9543634
Ustd=220353.831877012
Neff=10000
HB=0
HC=0
HR=0
IO=0

[COMP 101]
Type=Temp
Definition='Interim quantity for regression statistics'
Unit='mg²/ml²'
Description=0
Fcov=2
NomUnit=
UncUnit=
CovID=0
UncID=0
Vnom=3.68759529995157
Ustd=0.0330742770821377
Neff=10000
HB=0
HC=0
HR=0
IO=0

[Correlations]
Coefficient[1,5]=0.8
Coefficient[1,9]=0.8
Coefficient[1,13]=0.8
Coefficient[1,17]=0.8
Coefficient[5,9]=0.8
Coefficient[5,13]=0.8
Coefficient[9,13]=0.8
Coefficient[5,17]=0.8
Coefficient[9,17]=0.8
Coefficient[13,17]=0.8
Coefficient[42,48]=0.8
Coefficient[42,54]=0.8
Coefficient[42,60]=0.8
Coefficient[42,66]=0.8
Coefficient[48,54]=0.8
Coefficient[48,60]=0.8
Coefficient[48,66]=0.8
Coefficient[54,60]=0.8
Coefficient[54,66]=0.8
Coefficient[60,66]=0.8
Coefficient[43,49]=0.8
Coefficient[43,55]=0.8
Coefficient[43,61]=0.8
Coefficient[43,67]=0.8
Coefficient[49,55]=0.8
Coefficient[49,61]=0.8
Coefficient[49,67]=0.8
Coefficient[55,61]=0.8
Coefficient[55,67]=0.8
Coefficient[61,67]=0.8
Description=0
Coefficient[41,47]=0.8
Coefficient[41,53]=0.8
Coefficient[41,59]=0.8
Coefficient[41,66]=0.8
Coefficient[47,53]=0.8
Coefficient[47,59]=0.8
Coefficient[47,66]=0.8
Coefficient[53,59]=0.8
Coefficient[53,66]=0.8
Coefficient[59,66]=0.8
Coefficient[42,67]=0.8
Coefficient[48,67]=0.8
Coefficient[54,67]=0.8
Coefficient[60,67]=0.8
Coefficient[41,65]=0.8
Coefficient[47,65]=0.8
Coefficient[53,65]=0.8
Coefficient[59,65]=0.8