Aleksandr Peet "Intrauterine and postnatal growth in children with HLA-conferred susceptibility to type 1 diabetes" | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    Lossi 3, 51003 Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    +372 737 6310
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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    Näituse 2, 50409 Tartu
  • School of Law
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  • Institute of Social Studies
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    Lossi 36, 51003 Tartu
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Faculty of Medicine
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Ravila 19, 50411 Tartu
  • Dean's Office
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
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    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
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  • Institute of Dentistry
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    Raekoja plats 6, 51003 Tartu
  • Institute of Clinical Medicine
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    Faculty address: 
    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51005 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
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    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
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    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
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    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
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    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
    Faculty phone: 
    +372 737 6339
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
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    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
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    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
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    +372 737 6215
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • Information Technology Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
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    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
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    Ülikooli 18-244, 51005 Tartu
  • Marketing and Communication Office
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    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
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    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
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    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
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    Ülikooli 18b, 51005 Tartu
  • University of Tartu Press
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    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
Other Units
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    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
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    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Aleksandr Peet "Intrauterine and postnatal growth in children with HLA-conferred susceptibility to type 1 diabetes"

Date: 
26.11.2015 - 15:00 to 17:00

Thesis supervisors Professor Vallo Tillmann (Department of Paediatrics, University of Tartu) and Professor Mikael Knip (University of Helsinki).

Opponent Senior Research Fellow Lars Christian Stene, PhD (Norwegian Institute of Public Health, Norway).

Summary
The incidence of type 1 diabetes (T1D) is increasing by 3-4% annually all over the world. T1D is an autoimmune disease where immune system destroys the insulin-producing β-cells in pancreas. T1D has a genetic susceptibility conferred by specific HLA genes. However, only ca 5% of people with genetic susceptibility develops T1D. Therefore it has been suggested that the reasons for the increasing incidence of T1D are related to the changes in living environment. 
 An increased birth weight and early childhood growth have been found to be risk factors for T1D. According to acceleration hypothesis, in modern Western society the food overload and consecutive obesity increase the insulin demand already from early childhood. The over activity of β-cells leads to their targeting by immune system and facilitates the onset of autoimmunity. 
 The role of genetic factors conferring susceptibility to T1D in pre- and postnatal (i.e. before and after birth) growth is unclear. Also, the role of one of the most important growth factors in childhood – insulin-like growth factor I (IGF-I) and its binding protein (IGFBP-3), is not clear. Previous studies have shown that both can play role in the development of T1D.
 As a part of large international study DIABIMMUNE, genetic risk by HLA genes was determined in ~9000 newborns born in three countries - Estonia, Finland and Russian Karelia. We investigated whether those genes affect the birth weight and postnatal growth. In ~500 children with increased genetic susceptibility to T1D we also studied whether IGF-I and IGFBP-3 influence childhood growth or are associated with β-cells autoimmunity.
 We have found that generally there was no significant association between the HLA genes and birth weight. However, children with highest genetic risk for T1D grew slower during the first 24 months and they had lower plasma IGF-I and IGFBP-3 levels compared with others. The children with signs of autoimmunity had lower IGF-I and their IGFBP-3 showed a faster increment just before the emerge of autoimmunity compared to children without signs of autoimmunity. 
 We conclude that HLA genes associated with T1D risk influence early childhood growth, but not birth weight. IGF-I and IGFBP-3 may have both role in early growth as well as in the development of T1D autoimmunity.

Organizer: 
Tuuli Ruus
Location: 
Linkbergi auditoorium (Puusepa 8)
Event category: