Innar Tõru "Serotonergic modulation of CCK-4-induced panic" | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    J. Liivi 4, 50409, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    +372 737 6310
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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    Näituse 2, 50409 Tartu
  • School of Law
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  • Institute of Social Studies
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Faculty of Medicine
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  • Institute of Biomedicine and Translational Medicine
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    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
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    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
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  • Institute of Clinical Medicine
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    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
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    +372 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51003 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
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    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
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    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
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  • Institute of Technology
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    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
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    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
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    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
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    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
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    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
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    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
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    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
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    Lossi 3, III floor, 51003 Tartu
  • Information Technology Office
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    Ülikooli 18, rooms 302 and 304, 50090 Tartu
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  • Marketing and Communication Office
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    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
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    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
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    Ülikooli 18, 50090 Tartu
  • Student Council
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  • University of Tartu Press
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    Faculty address: 
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    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
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  • Tartu University Hospital
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  • University of Tartu Foundation
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  • View all other units

Innar Tõru "Serotonergic modulation of CCK-4-induced panic"

Date: 
28.08.2012 - 15:00 to 17:00

Supervisors: Professor Veiko Vasar (University of Tartu), Professor Eduard Maron (University of Tartu), Assistant Professor Jakov Šlik (University of Ottawa, Canada).

Opponent: Professor Michael Kellner, Dr. med. (University of Hamburg, Germany)

Summary:
Panic disorder (PD) characterized by recurrent unexpected panic attacks (PA) and persisting fear of their recurrence, is a frequent mental health problem, often associated with serious impairment.

Experimental panic induction with cholecystokinin-tetrapeptide (CCK-4) has been established as a valid experimental model of human panic attacks. Several studies have investigated the interaction patterns between CCK and other (most intriguing among these probably serotonin (5-HT)) neurotransmitter systems. Earlier studies have suggested that patients with panic disorder and healthy controls differ in their sensitivity to CCK-4 challenge as well as in their responsiveness to serotonergic modulation of this sensitivity. Studies suggest that these dissimilarities may at least partly be explained by the differences in the brain 5-HT receptor and transporter systems as well as in the genes regulating 5-HT system.

The general objective of the present work was to study the modulating role of the 5-HT system on CCK-4-induced panic response. Apart from the effects of direct pharmacological manipulation of synaptic 5-HT levels, some factors of hypothetical importance, such as gene polymorphisms and binding properties of 5-HT transporter system were investigated.

The main findings of the present study were as follows:
1. Acute decline in the central availability of 5-HT by means of tryptophan depletion did not reverse the protective effect of SSRI treatment on CCK-4-induced panic.
2. On a panel of candidate genes, only rs1386494 A/G polymorphism in TPH2 gene was associated with CCK-4-induced panic attacks in HV with the frequencies of G/G genotype and G allele significantly higher in panickers.
3. Serotonin transporter non-displaceable binding potential (5-HTT BPND) was significantly higher in 13 of 20 studied brain regions, including several cortical and raphe areas, but lower in the hippocampus in males with PD as compared with healthy males. No significant differences in 5-HTT BPND were observed between female patients and controls.
4. The treatment with an SSRI escitalopram did not reduce the CCK-4-induced PA in CCK-4-sensitive HV beyond the effect of placebo in contrast to the findings in patients with PD

To conclude, it would apparently be an oversimplification to consider 5-HT system as the single or primary modulatory factor in determining the CCK-4-induced panic response as well as to assume a direct modulatory effect of 5-HT on CCK-4 induced panic. The molecular and receptor mechanisms behind the 5-HT effects on panic manifestations observed in the context of CCK-4 challenge warrant further studies.

Organizer: 
Location: 
Ravila Street 19, room 1038
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