Jelena Beljantseva "Small fine-tuners of the bacterial stringent response - a glimpse into the working principles of Small Alarmone Synthetases" | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
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    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
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    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
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    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
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    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
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    Lossi 3, 51003 Tartu
  • Viljandi Culture Academy
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    +372 435 5232
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    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
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Lossi 36, 51003 Tartu
  • Dean's Office
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    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
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    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
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    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
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    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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  • Institute of Biomedicine and Translational Medicine
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  • Institute of Pharmacy
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  • Institute of Dentistry
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  • Institute of Clinical Medicine
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    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
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    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
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+372 737 5820
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Vanemuise 46–208, 51014 Tartu
  • Dean's Office
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    Faculty address: 
    Vanemuise 46–208, 51005 Tartu
  • Institute of Computer Science
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    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
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    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
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  • Institute of Chemistry
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    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
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    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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  • Tartu Observatory
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  • Institute of Technology
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  • Institute of Ecology and Earth Sciences
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    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
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    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
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    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
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    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
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    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
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    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
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    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
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    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
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    Lossi 3, III floor, 51003 Tartu
  • Information Technology Office
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  • Human Resources Office
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  • Marketing and Communication Office
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    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
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    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
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    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
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    Ülikooli 18, 50090 Tartu
  • Student Council
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  • University of Tartu Press
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    Faculty address: 
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Other Units
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    Faculty address: 
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  • Tartu University Hospital
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  • University of Tartu Foundation
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  • View all other units

Jelena Beljantseva "Small fine-tuners of the bacterial stringent response - a glimpse into the working principles of Small Alarmone Synthetases"

Date: 
19.08.2020 - 12:15

On 19th of August at 12:15 Jelena Beljantseva will defend her doctoral thesis „Small fine-tuners of the bacterial stringent response – a glimpse into the working principles of Small Alarmone Synthetases"

Supervisors: senoir researcher Vasili Hauryliuk, professor Tanel Tenson (University of Tartu, Institute of Technology)

Opponent: professor Kaspars Tārs, University of Latvia (Universitas Latviensis), Latvia

Summary:
Bacteria, being the most abundant organisms in the world, live and survive in the most extreme and unreachable places of our planet. They are able to withstand such conditions as extreme cold or heat, excessive salinity, lack of oxygen etc. Moreover, for pathogenic bacteria, immune system of the host organism is also a challenge to put up with.

In order to combat hostile and continuosly changing conditions bacteria have evolved regulatory mechanisms to sense the environmental cues and change their physiology in response. One of the most global such mechanism is the stringent response. This process is mediated by the alarmone molecule named (p)ppGpp which is synthesized in bacterial cell in response to nutrient, heat and other stresses. Accumulation of this molecule leads to reprogramming of bacterial physiology such that growth and division are repressed and survival mechanisms are upregulated. This leads to increased viability of bacterium in adverse conditions. Stringent response is also implicated in virulence, antibacterial resistance and biofilm formation, therefore making this process an important study subject from the clinical point of view.

(p)ppGpp levels are regulated by the representatives of RelA-SpoT Homolog (RSH) family of proteins. These enzymes are highly conserved among bacteria due to their evolutionary importance and the universal nature of the stringent response in bacteria. In this thesis, I contribute to knowledge on RSH enzymes by taking a glimpse into working mechanisms of Small Alarmone Synthetases (SAS) – so far not so well studied RSH representatives. Specifically, I have investigated the enzymatic characteristics of two SAS: Enterococcus faecalis RelQ and Staphylococcus aureus RelP. The distinctive features of the working principles found for these proteins underlay their role in fine-tuning the stringent response.

 

Organizer: 
Tanel Tenson
Location: 
Nooruse 1–121
Event category: