Karita Raudkivi "Neurochemical studies on inter-individual differences in affect-related behaviour of the laboratory rat" | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
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    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
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    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    J. Liivi 4, 50409, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
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Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
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    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
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    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
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    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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  • Institute of Biomedicine and Translational Medicine
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  • Institute of Pharmacy
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    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
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Vanemuise 46–208, 51014 Tartu
  • Dean's Office
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    Faculty address: 
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  • Institute of Computer Science
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    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
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    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
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    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
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    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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  • Tartu Observatory
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  • Institute of Technology
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  • Institute of Ecology and Earth Sciences
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    Vanemuise 46, 51003 Tartu
Institutions
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    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
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    Uppsala 10, 51003 Tartu
  • Institute of Genomics
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    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
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    +372 737 5674
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    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
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    Vanemuise 46, 51003 Tartu
Support Units
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    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
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    Faculty address: 
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  • Estates Office
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    Faculty address: 
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  • Finance Office
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    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
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    Ülikooli 18, 50090 Tartu
  • Procurement Office
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    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
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    Ülikooli 18, 50090 Tartu
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  • University of Tartu Press
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  • View all other units

Karita Raudkivi "Neurochemical studies on inter-individual differences in affect-related behaviour of the laboratory rat"

Date: 
19.11.2012 - 09:30 to 11:30

Supervisors: Prof. Jaanus Harro
Prof. Ivo Leito

Opponent: Prof. Artur Swiergiel

Summary:
The present dissertation focuses on the neurochemical mechanisms associated with behaviour in depression-related states using different analytical methods and animal models of depression.
Inter-individual differences, that are probably caused by variations in the regulation of neurochemical pathways, exist between organisms, and are likely to be significant in the pathogenesis of affective disorders. Depression is a highly prevalent psychopathological condition. In order to investigate depression the tests based on exploratory behaviour of rats are mostly used. Exploratory behaviour is very much dependent on the function of the noradrenergic projections of the locus coeruleus. All rats with near complete denervation of these projections behave in the exploration box test like the spontaneous LE-phenotype that has been associated with less efficient dopaminergic neurotransmission. It appeared that extensive denervation of the noradrenergic projections from locus coeruleus indeed reduced the effect of cocaine-induced place preference and locomotor activation.
Early life experiences may also affect neurochemical mechanisms and thereby influence the behavioural pattern later in life. Thus, the effect of maternal separation (as the early life stress) on alcohol consumption was studied. It appeared that animals that experienced maternal separation had low serotonin levels in amygdala and responded with an increase in serotonin after ethanol intake, which is a key area in addiction processes.
Studies in the present dissertation indicate that rats with different exploratory phenotype differ, in addition to catecholaminergic mechanisms, also with regard to regulation of serotonergic and glutamatergic systems. Serotonergic neurotransmission in hippocampus and prefrontal cortex was found to be regionally differentially regulated in HE- and LE-rats. In prefrontal cortex, the LE-rats had higher extracellular serotonin levels induced by citalopram and higher levels of serotonin transporter binding. In dentate gyrus, contrary, the HE-rats had higher levels of extracellular serotonin. Additionally, HE-rats had increased levels of glutamate after blockade of glutamate transporter in striatum.
Predisposition to express positive affect at low levels had previously been linked to vulnerability to depression. We could confirm the higher sensitivity of the LC-rats that produce less 50-kHz vocalizations to chronic stress: they gained weight more slowly and had higher corticosterone levels measured from full blood after stress. LC-rats have also differences in serotonergic mechanisms after chronic stress was supported by the finding that stressed LC-rats had higher extracellular serotonin levels induced by citalopram in hippocampus, where serotonergic system has been known to mediate response to anxious stimuli. These findings support the notion that male rats with low 50-kHz USVs response to tickling, having lower positive emotionality, are behaviourally more vulnerable to stress.
Taken together, the consideration of these neurobiological differences between individuals could lead to novel approaches to more personalized medical treatment of depression-related states.

Keywords: depression, negative and positive affect, exploratory behaviour, noradrenaline, serotonin, glutamate, inter-individual differences, ultrasonic vocalization, stress, alcohol consumption.

Organizer: 
Location: 
Nooruse Street 1, room 121
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