Katrin Sikk "Manganese-ephedrone intoxication - pathogenesis of neurological damage and clinical symptomatology" | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    J. Liivi 4, 50409, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
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    +372 737 6310
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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    Näituse 2, 50409 Tartu
  • School of Law
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  • Institute of Social Studies
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Faculty of Medicine
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Ravila 19, 50411 Tartu
  • Dean's Office
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
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    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
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    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
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    Raekoja plats 6, 51003 Tartu
  • Institute of Clinical Medicine
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    Faculty address: 
    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51003 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
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    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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  • Tartu Observatory
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  • Institute of Technology
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    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
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    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
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    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
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    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
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    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
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    +372 737 5674
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    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
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    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
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    Faculty address: 
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  • Centre for Entrepreneurship and Innovation
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    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
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    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
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    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
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    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
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    Faculty address: 
    Raekoja plats 9, 51004 Tartu
  • Information Technology Office
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    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
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    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
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  • Marketing and Communication Office
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    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
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    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
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    Ülikooli 18, 50090 Tartu
  • Student Council
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  • University of Tartu Press
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    Faculty address: 
    W. Struve 1, 50091 Tartu
Other Units
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    Faculty address: 
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  • University of Tartu Foundation
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  • View all other units

Katrin Sikk "Manganese-ephedrone intoxication - pathogenesis of neurological damage and clinical symptomatology"

Date: 
29.05.2013 - 15:00 to 17:00

Supervisors: dotsent Sulev Haldre (TÜ närvikliinik), dotsent Pille Taba (TÜ närvikliinik) ja professor Sten-Magnus Aquilonius (Uppsala Ülikool, Rootsi).

Opponent: professor Per Odin, MD, PhD (Bremerhaveni Keskhaigla, Saksamaa/ Skane Ülikooli Kliinik, Lund, Rootsi)

Summary:
There are many causes of parkinsonian syndromes, among them Parkinson's disease is the most common. Neurodegenerative diseases, drugs, structural lesions, cerebrovascular diseases, infections and toxicants can all induce parkinsonism. This study describes parkinsonian syndrome in drug addicts, who had injected home-made psychostimulant mixture made of pseudoephedrine, potassium permanganate, acetic acid and boiling water. In the oxidation reaction, pseudoephedrine was converted to ephedrone (methacathinone). As a toxic by-product of the synthesis the final mixture contained high concentration of manganese. The intravenously administered daily manganese load was almost 2000 times higher than recommended. During 2006 till 2012, we examined 38 patients with a mean age of 33 years. The main motor symptoms were postural instability, gait disorder and speech impairment, limb dystonia and bradykinesia. The clinical symptomatology resembled classic manganese intoxication. There was no correlation between the duration of drug abuse and the severity of symptoms, i.e. a severe motor impairment could develop only after a short time of ephedrone abuse. The syndrome was irreversible after cessation of exposure and there was a trend of worsening. Magnetic resonance imaging showed increased signal intensity in globus pallidus and substantia nigra, these findings are specific to manganese exposure. Molecular neuroimaging studies showed the preservation of dopaminergic neurons, which are decreased in Parkinson's disease. Ephedrone abuse is an imortant cause of parkinonism in young Estonian patients. Identifying the cause of an extrapyramidal syndrome in former ephedrone abusers could be difficult, because there are no specific laboratory or imaging findings. Recognising the typical clinical picture and detailed history taking about previous drug abuse, helps to avoid further expensive and unnecessary investigations. The use of homemade manganese-contaminated ephedrone causes significant motor impairmet and decline in quality of life. Preventive measures could reduce the direct and indirect expenses on rehabilitation and social services.

Organizer: 
Location: 
Puusepa Street 8, Linkberg's auditorium
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