Kuldar Kaljurand "Prevalence of exfoliation syndrome in Estonia and its clinical significance" | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    Lossi 3, 51003 Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    +372 737 6310
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
    Faculty phone: 
    +372 737 5902
    Faculty address: 
    Näituse 2, 50409 Tartu
  • School of Law
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    Faculty address: 
    Näituse 20–324, 50409 Tartu
  • Institute of Social Studies
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    Lossi 36, 51003 Tartu
  • Narva College
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    Raekoja plats 2, 20307 Narva
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    Ringi 35, 80012 Pärnu
Faculty of Medicine
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+372 737 5326
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Ravila 19, 50411 Tartu
  • Dean's Office
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    +372 737 5326
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
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    +372 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
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    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
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    Faculty address: 
    Raekoja plats 6, 51003 Tartu
  • Institute of Clinical Medicine
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    Faculty address: 
    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
    Faculty phone: 
    +372 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51005 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
    Faculty phone: 
    +372 737 5027
    Faculty address: 
    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
    Faculty phone: 
    +372 737 4510
    Faculty address: 
    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
    Faculty phone: 
    +372 737 4800
    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    +372 737 5835
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
    Faculty phone: 
    +372 737 5606
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
    Faculty phone: 
    +372 737 6339
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
    Faculty phone: 
    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
    Faculty phone: 
    +372 737 6215
    Faculty address: 
    Lossi 3, III floor, 51003 Tartu
  • Information Technology Office
    Faculty phone: 
    +372 737 6000, IT-help: +372 737 5500
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
    Faculty phone: 
    +372 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
    Faculty address: 
    Ülikooli 18-244, 51005 Tartu
  • Marketing and Communication Office
    Faculty phone: 
    +372 737 5687
    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
    Faculty phone: 
    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
    Faculty phone: 
    +372 737 6632
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
    Faculty phone: 
    +372 737 5600
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
    Faculty address: 
    Ülikooli 18b, 51005 Tartu
  • University of Tartu Press
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
Other Units
  • University of Tartu Academic Sports Club
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Kuldar Kaljurand "Prevalence of exfoliation syndrome in Estonia and its clinical significance"

Date: 
18.10.2013 - 14:00 to 16:00

Supervisor: dotsent Päivi M Puska (Helsingi Ülikool, Soome)
Opponent: professor Eija Vesti, MD, PhD (Turu Ülikool, Soome)

Summary:
Exfoliation syndrome (EXS) also called pseudoexfoliation, was first described by the Finnish ophthalmologist J.G.Lindberg in 1917 as small white spots at the papillary border and on the lens capsule, depigmentation of the papillary border and translucency of the iris in catar actous, glaucomatous and normal elderly persons (Lindberg 1917). EXS is an age-related condition with generalised dis-order of the extracellular matrix (ECM) characterized by a pathological accu-
mulation of polymorphic fibrillar extracellular material in the anterior segment of the eye (Schlötzer-Schrehardt & Nauman 2006)
Exfoliative material (EXM) appears to be attached to various intraocular tissues such as the lens epithelium, nonpig mented ciliary epithelium, trabecular epithelium, corneal endothelium, vascular endothelial cells and almost all cell types of the iris (Ritch & Schlötzer-Schrehardt 2001) EXM has also been identified in various tissues of the body, primarily in the connective tissue portion of the visceral organs (Schlötzer-Schrehardt & Nauman 2006) as well as the walls of the short posterior ciliary arteries and vortex
veins (Schlötzer-Schrehardt 1991). Elevated intraocular pressure (IOP) has been reported in eyes with EXS
(Arnarsson 2007, 2009; Mitchell et al. 1999; Kozart 1982). Patients with EXS are twice as likely to convert from ocular hypertension to glaucoma (Leske EMGT 2003) and are more likely to develop glaucoma at all IOPs (Topouzis 2009). Patients with exfoliative, also known as capsular, glaucoma (EXG) have a greater mean IOP, greater diurnal IOP fluctuation (Konstas et al. 1997), more visual field loss and optic disc damage at diagnosis, poorer response to medication, and greater need for surgical intervention, more rapid progression and a greater proportion of blindness (Ritch 2008). It has been suggested that increased
lens opacification is associated with EXS (Hirvelä 1995; Hietanen 1992). However, it has been difficult to evaluate the direct risk factor for cataract formation, in terms of whether it is high IOP, glaucoma, glaucoma treatment or exfoliative process itself. EXS is known to be a major risk factor in modern extracapsular cataract surgery and phacoemulsification. The risk of intraoperative problems, such as a poorly dilating pupil, zonular rupture, capsular break, and vitreous loss and postoperative complications including fibrinoid reaction, posterior synechias, cell deposits, and capsule contraction, is higher in eyes with the syndrome that
have extracapsular cataract extraction (Skuta et al. 1987; Zetterström et al. 1992; Guzek et al. 1997) or phacoemulsification (Dosso et al. 1997; Hayashi et al. 1998; Scorolli et al. 1998; Shastri & Vasavada 2001). Other ocular manifestations include dry eye (Kozobolis 1999), lens (and artificial intraocular lens) sub-luxation (Hayashi 1998; Breyer 1999), angle closure
and retinal vein occlusion (Ritch 2010). Specular and electron microscopic studies have revealed both quantitative and qualitative corneal endothelial cell changes in eyes with EXS. EXS eyes 10 have been found to have a lower endothe lial cell density than in non-EXS eyes. Changes in the percentage of hexagonal cells and the coefficient of variation of cell size have been shown when compared to eyes without EXS (Naumann & Schlötzer-Schrehardt 2000; Inoue et al. 2003; Wali et al. 2009). The characteristic tissue alterations predispose to co rneal endothelial decompensations which make them vulnerable during intraocular surgery, especially in cataract phacoe-mulsification. This clinical study was designed to examine the prevalence of EXS in Estonia and among patients scheduled for cataract surgery. The vulnerability of the corneal endothelium during cataract phakoe mulsification in patients with or without EXS was also studied.

Organizer: 
Location: 
Ravila Street 19, room 1038
Event category: