Lille Kurvits “Parkinson’s disease as a multisystem disorder: whole transcriptome study in Parkinson’s disease patients’ skin and blood” | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    J. Liivi 4, 50409, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
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    +372 737 6310
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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  • School of Law
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  • Institute of Social Studies
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Faculty of Medicine
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+372 737 5326
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Ravila 19, 50411 Tartu
  • Dean's Office
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
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    Faculty address: 
    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
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  • Institute of Dentistry
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  • Institute of Clinical Medicine
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  • Institute of Family Medicine and Public Health
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51003 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
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    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
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    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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    Faculty address: 
    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
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    Faculty address: 
    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
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    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    +372 737 5835
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
    Faculty phone: 
    +372 737 5606
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
    Faculty phone: 
    +372 737 4809
    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
    Faculty phone: 
    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
    Faculty phone: 
    +372 737 6215
    Faculty address: 
    Raekoja plats 9, 51004 Tartu
  • Information Technology Office
    Faculty phone: 
    +372 737 6000, IT-help: +372 737 5500
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
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    +372 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
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    Ülikooli 18-244, 51005 Tartu
  • International Cooperation and Protocol Office
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    +372 737 6123
    Faculty address: 
    Ülikooli 18, rooms 104, 301, 305, 50090 Tartu
  • Marketing and Communication Office
    Faculty phone: 
    +372 737 5687
    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
    Faculty phone: 
    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
    Faculty phone: 
    +372 737 6632
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
    Faculty phone: 
    +372 737 5600
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
    Faculty address: 
    Ülikooli 18b, 51005 Tartu
  • University of Tartu Press
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
Other Units
  • University of Tartu Academic Sports Club
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Lille Kurvits “Parkinson’s disease as a multisystem disorder: whole transcriptome study in Parkinson’s disease patients’ skin and blood”

Date: 
15.06.2021 - 12:00
On 15 June at 12:00 Lille Kurvits will defend her doctoral thesis “Parkinson’s disease as a multisystem disorder: whole transcriptome study in Parkinson’s disease patients’ skin and blood”.
 
Supervisors:
Professor Pille Taba, University of Tartu
Professor Sulev Kõks, University of Tartu/Murdoch University (Australia)
Research Fellow Anu Planken, University of Tartu
 
Opponent:
Professor Christine Klein, University of Luebeck/University Hospital Schleswig-Holstein (Germany)
 
Summary
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease with a diagnostic complexity as there are currently no reliable biomarkers for PD. PD is a movement disorder characterized by slowness of voluntary movement (bradykinesia), rigidity and resting tremor. The pathophysiology of PD converges into pathognomonic loss of dopaminergic neurons in substantia nigra of the central nervous system and the accumulation of pathologic protein α-synuclein into Lewy bodies in neurons. Most PD cases are sporadic and large genome wide association studies show that gene variance alone is not the main cause of PD occurrence. This work, therefore, investigates gene expression (transcriptomics) of PD in search of feasible diagnostic and prognostic biomarkers. The tissue which the sample is taken from is relevant in transcriptomics, because gene expression is tissue specific. PD has canonically seen as a disease of the dopaminergic neurons in the central nervous tissue, but this tissue cannot be sampled from living patients. It is, therefore, necessary to find other tissues that allow sampling in vivo for biomarker research. A potential tissue of interest is the skin because PD patients have more melanoma and other specific skin conditions compared to the general population. Another promising tissue next to skin is the blood, because it is the easiest to sample and circulating the whole organism carries a lot of systemic information. The current work profiles gene expression from skin and blood using RNA sequencing in order to explore the disease specific involvement of nonneuronal peripheral tissues in PD. The results from PD skin show a pattern of global downregulation of differentially expressed genes that mirrors the pathophysiology of PD in the brain. Changes that lead to vulnerability in PD skin to mutagenic hazards are also mapped that might explain the epidemiologically observed elevated prevalence of melanoma in PD patients. This suggests that gene expression in the skin, a peripheral nonneuronal tissue, is PD-specifically changed. The results from PD blood show notably fewer changes, however, most are previously described in PD. This highlights the difficulty in using blood for biomarker discovery as the tissue is heterogeneous and the results are not easily reproducible. No overlapping differentially changed gene expressions are found in comparison of the two tissues in PD, which underlines the importance of tissue specific differences in gene expression. The study highlights notable differential gene expressions that show most robust changes and warrant further functional studies to evaluate their biomarker potential.
Location: 
Ravila 19-1006 or via videobridge
URL: 
https://dspace.ut.ee/handle/10062/71931
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