Maria Yakoreva „Imprinting disorders in Estonia“

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View all other units

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Date:

26.08.2019 - 15:00

On 26. August at 15.00 Maria Yakoreva will defend her doctoral thesis „Imprinting disorders in Estonia“.

Supervisors:
professor Katrin Õunap, University of Tartu
lecturer Tiina Kahre, University of Tartu

Opponent:
professor Bernhard Horsthemke (PhD), Medical Faculty, Universität Duisburg-Essen, Germany

Summary:
Congenital imprinting disorders (ImpDis) are a little-known group of rare hereditary diseases caused by changes in the expression of imprinted genes, mainly affecting growth, brain functions and the hormonal system. Although at least 100 imprinted genes have been found in the human genome, only 13 clinically recognizable ImpDis are currently known. The most common of these are Prader-Willi syndrome (PWS), Angelman syndrome (AS), Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS). Although each ImpDis has its own specific clinical features, the symptoms are often overlapping, atypical, or mildly expressed. The molecular causes of ImpDis can be genetic as well as epigenetic. Because of the high variability of the clinical phenotype and molecular alterations, the diagnosis of ImpDis is difficult, and many ImpDis cases remain therefore undiagnosed.
This study clarified the prevalence of the most frequent ImpDis in Estonia. The birth prevalence of PWS, AS and BWS in Estonia is comparable with the prevalence previously reported in the literature, but the birth prevalence of SRS and GNAS-gene-related ImpDis is significantly higher than previously estimated. It was demonstrated that although each ImpDis, taken separately, is very rare, all ImpDis together are relatively common. Molecular diagnostic tests confirmed the diagnosis in 38% of patients with clinical diagnosis of SRS and in 8% of patients with clinical diagnosis of BWS, indicating that in Estonia the clinical scoring system for SRS is more effective than those for BWS. New molecular diagnostic tests, such as MS-MLPA (Methylation-Specific Multiplex Ligation-dependent Probe Amplification) of imprinted loci in chromosomes 6, 7, 14 and 20, were introduced into the laboratory practice in Estonia, and rare ImpDis found by these analyses were described. As a result of this study, the diagnostics of ImpDis has been improved in Estonia, and the awareness of ImpDis among Estonian doctors has been increased.

Location:

Puusepa 8, Linkbergi auditoorium

URL:

hdl.handle.net/10062/64803

Event category:

Defence

M	T	W	T	F	S	S
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2 Opening of ‘Faces of the University III’ photo exhibition on wall of von Bock building UT opening ceremony of the 2019/2020 academic year Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	3 Opening concert of the academic year: Atlan Karp and Piia Paemurru Ülle Võhma „Association between personality traits, clinical characteristics and pharmacological treatment response in panic disorder“ Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	4 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	5 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	6 Van Thai Nguyen „The first study of the treatment outcomes of patients with cleft lip and palate in Central Vietnam“ Kalev Erme „The effect of catalysts in plasma oxidation of nitrogen oxides” Ann Siiman „Vormikasutuse varieerumine ning selle põhjused osastava ja sisseütleva käände näitel“ Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	7 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	8 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”
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30 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”

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Maria Yakoreva „Imprinting disorders in Estonia“

September