Marina Grigorova "Fine-scale genetic variation of follicle-stimulating hormone beta-subunit coding gene (FSHB) and its association with reproductive health" | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    J. Liivi 4, 50409, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
    Faculty phone: 
    +372 737 6310
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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    Faculty address: 
    Näituse 2, 50409 Tartu
  • School of Law
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  • Institute of Social Studies
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  • Narva College
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  • Pärnu College
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Faculty of Medicine
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Ravila 19, 50411 Tartu
  • Dean's Office
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    +372 737 5326
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
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    +372 737 4210
    Faculty address: 
    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
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    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
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    Raekoja plats 6, 51003 Tartu
  • Institute of Clinical Medicine
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    Faculty address: 
    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
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    +372 737 4190
    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51003 Tartu
  • Institute of Computer Science
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    +372 737 5445
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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    Faculty address: 
    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
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    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
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    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    +372 737 5835
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
    Faculty phone: 
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
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    +372 737 4809
    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
    Faculty phone: 
    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
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    +372 737 6215
    Faculty address: 
    Raekoja plats 9, 51004 Tartu
  • Information Technology Office
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    +372 737 6000, IT-help: +372 737 5500
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
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    +372 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
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    Ülikooli 18-244, 51005 Tartu
  • Marketing and Communication Office
    Faculty phone: 
    +372 737 5687
    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
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    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
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    +372 737 5600
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
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    Ülikooli 18b, 51005 Tartu
  • University of Tartu Press
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    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
Other Units
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    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
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    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
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    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Marina Grigorova "Fine-scale genetic variation of follicle-stimulating hormone beta-subunit coding gene (FSHB) and its association with reproductive health"

Date: 
25.11.2011 - 14:00 to 16:00

Reedel, 25. novembril 2011. aastal kell 14.00 kaitseb Marina Grigorova Tartu Ülikooli Molekulaar- ja rakubioloogia Instituudis Riia 23-217 doktoritööd "Fine-scale genetic variation of follicle-stimulating hormone beta-subunit coding gene (FSHB) and its association with reproductive health" ("Folliikuleid-stimuleeriva hormooni beeta-alaühikut kodeeriva geeni (FSHB) järjestuse varieeruvus ja selle seos reproduktiivtervisega") molekulaarse biomeditsiini erialal.

Juhendaja: TÜ MRI professor Maris Laan.

Oponent: professor Ilpo Huhtaniemi, Paljunemise- ja Arengubioloogia Instituut, Londoni Riiklik Kolledž, London, Suurbritannia.

Folliikuleid stimuleeriv hormoon (FSH) on gonadotropiin, mis reguleerib mõlema sugupoole sugurakkude teket ja küpsemist ning suguhormoonide tootmist. FSH on valk, mis koosnevad kahest alaühikust. Hormooni spetsiifilise toime ja retseptoriga seondumise määrab ß-alaühik. FSH ß-subühikut kodeerib FSHB geen.
Käesoleva doktoritöös uuriti FSHB geeni ülemaailmset varieeruvust (Euroopa, Aafrika ja Aasia populatsioonid). Uuritud populatsioonides on levinud kõrge sagedusega ühenukleotiidsed polümorfismid, mis paiknevad valdavalt geeni mittekodeerivas piirkonnas ning mille alleelide vahel on täielik alleelne assotsiatsioon. FSHB geen on esindatud kahe tuumhaplotüübiga, mis erinevad üksteisest igas polümorfses positsioonis. Euroopa populatsioonides on mõlemad haplotüübid levinud võrdse sagedusega, mitte-Euroopa populatsioonides esineb valdavalt FSHB geeni haplotüüp 1. Kuigi FSHB geeni tuumhaplotüüpide puhul on kodeeritav valk sarnase aminonappelise järjestusega, võivad tuumhaplotüüpide polümorfismid seonduda geenis ja sellega piirneval alal regulatoorse alaga, mis mõjutab geeni avaldumist. Pilootuuringu tulemusena ilmnes, et kiirelt rasestuvate viljakate naiste hulgas leidus enam FSHB geeni teise tuumhaplotüübi kandjaid.
Lisaks uuriti seosed FSHB geeni avaldumist mõjutavat regulatoorse polümorfismi -211 G/T ja mehe reproduktiivsete parameetrite vahel. Geneetilise assotsiatsiooni analüüsi tulemusena ilmnes oluline seos polümorfismi alleelide ja meeste seerumi FSH taseme vahel. Nii Baltimaade noorte meeste kui ka Eesti viljatute meeste hulgas, oli GT- ja TT-genotüüpide kandjatel vastavalt 16-35% ja 30-50% madalam FSH väärtus võrreldes GG-genotüüpi kandjatega. Lisaks FSH-le polümorfism seondub ka teiste hormonaalsete ja munandi funktsiooni näitavate parameetritega. TT-genotüübi kandjatel on 20% väiksem munandite kogumaht võrreldes GG- ja GT-genotüüpide kandjatega. Polümorfismi seosed mitme meeste reproduktiivtervise parameetriga viitavad madala FSH taseme võimalikele pika- ja lühiajalistele efektitele reproduktiivpotentsiaalile.

Location: 
Riia 23-217
Event category: