Martin Pook “Studies on artificial and extracellular matrix protein-rich surfaces as regulators of cell growth and differentiation” | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
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    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
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    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
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    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
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    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
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    J. Liivi 4, 50409, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
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    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
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Lossi 36, 51003 Tartu
  • Dean's Office
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    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
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    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
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    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
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  • Institute of Psychology
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  • Institute of Biomedicine and Translational Medicine
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  • Institute of Pharmacy
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  • Institute of Clinical Medicine
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  • Institute of Sport Sciences and Physiotherapy
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    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
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Vanemuise 46–208, 51014 Tartu
  • Dean's Office
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    Faculty address: 
    Vanemuise 46–208, 51003 Tartu
  • Institute of Computer Science
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    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
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    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
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    Faculty address: 
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  • Institute of Mathematics and Statistics
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  • Institute of Molecular and Cell Biology
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  • Tartu Observatory
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  • Institute of Technology
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  • Institute of Ecology and Earth Sciences
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    Vanemuise 46, 51003 Tartu
Institutions
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    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
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    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Museum
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    +372 737 5674
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    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
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    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
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    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
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    Faculty address: 
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  • Estates Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
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    Jakobi 4, 51005 Tartu
  • Grant Office
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    Raekoja plats 9, 51004 Tartu
  • Information Technology Office
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  • Human Resources Office
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    Ülikooli 18, rooms 302 and 304, 50090 Tartu
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  • Marketing and Communication Office
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    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
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    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
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    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
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    Ülikooli 18, 50090 Tartu
  • Student Council
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  • University of Tartu Press
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Other Units
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  • Tartu University Hospital
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  • University of Tartu Foundation
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  • View all other units

Martin Pook “Studies on artificial and extracellular matrix protein-rich surfaces as regulators of cell growth and differentiation”

Date: 
09.06.2015 - 15:00

Thesis supervisor: UT Senior Associate Professor Sulev Ingerpuu, UT professor Toivo Maimets ja UT Senior Research Fellow Viljar Jaks

Opponent: Professor dr. Gerd Klein, University of Tübingen

Summary
All animal cells interact with extracellular matrix (ECM) either continuously or during important phases of their life-time. ECM provides mechanical support for tissues and is thus necessary for building up organs with complex structures. The interactions between cells and ECM regulate cell growth, migration and differentiation. The major components of ECM are proteins and polysaccharides that are secreted by various cell types. Collagens and laminins are examples of widely-studied ECM proteins. 
The research presented in the current thesis was designed to study the ways in which cells interact with the surrounding extracellular matrix and how these bidirectional interactions affect cell growth and differentiation. Firstly, we studied how topographical properties of silica-based surfaces  affect the growth of human dermal fibroblasts. Surfaces with four different sizes of round structural elements were produced (200 nm, 500nm, 1 µm ja 10 µm). It was found that increase in the size of these structural elements coincided with the decrease in cell growth and induced cell senescence. The second study demonstrated that electrospun gelatin-based scaffolds that contain glucose are suitable for growth of primary dermal fibroblasts. These scaffolds induced expression of ECM proteins such as laminins in fibroblasts. The third study investigated the localization and secretion of laminins in human platelets. Our investigation revealed that platelets do not store laminins in typical alpha granules as was shown previously, and that these proteins are secreted via microvesicles but not via exosomes when platelets become activated. The fourth study of this thesis characterized the expression of laminins in human embryonic stem cells. We observed that the relative amount of laminin-511 increases while the amount of laminin-521 decreases during early differentiation induced by retinoic acid. Additionally, we found that human embryonic stem cells express a wider range of different laminin chains than previously described, and that the laminin repertoire was independent of their differentiation status.

Organizer: 
Tiina Tamm
Location: 
Riia 23B, Estonian Biocentre, room 105
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