Mikk Puustusmaa „On the origin of papillomavirus proteins”

Contacts of UT units

Dean's Office

Faculty contacts link:
Employee contacts

Faculty phone:
+ 372 737 5341

Faculty email:
hv.dekanaat [at] ut.ee

Faculty address:
Jakobi 2, rooms 116–121, 51005 Tartu
Institute of History and Archaeology

Faculty link:
www.flaj.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5651

Faculty address:
Jakobi 2, 51005 Tartu
Institute of Estonian and General Linguistics

Faculty link:
keel.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5221

Faculty email:
keeleteadus [at] ut.ee

Faculty address:
Jakobi 2, 51005 Tartu
Institute of Philosophy and Semiotics

Faculty link:
www.flfi.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5314

Faculty email:
filosoofia.semiootika [at] ut.ee

Faculty address:
Jakobi 2, rooms 309–352, 51005 Tartu
Institute of Cultural Research

Faculty link:
www.flku.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
(+372) 737 5223

Faculty email:
kultuuriteadused [at] ut.ee

Faculty address:
Ülikooli 16, 51003 Tartu
School of Theology and Religious Studies

Faculty link:
us.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5301

Faculty email:
us [at] ut.ee

Faculty address:
Ülikooli 18–310, 50090 Tartu
College of Foreign Languages and Cultures

Faculty link:
maailmakeeled.ut.ee

Faculty contacts link:
Employee contacts

Faculty email:
keeled [at] ut.ee

Faculty address:
J. Liivi 4, 50409, Tartu
Viljandi Culture Academy

Faculty link:
kultuur.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 435 5232

Faculty email:
kultuur [at] ut.ee

Faculty address:
Posti 1, 71004 Viljandi

Dean's Office

Faculty contacts link:
Employee contacts

Faculty phone:
+ 372 737 5900

Faculty email:
sotsiaalteadused [at] ut.ee

Faculty address:
Lossi 36, 51003 Tartu
Institute of Education

Faculty link:
www.ht.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 6440

Faculty email:
haridus [at] ut.ee

Faculty address:
Salme 1a–29, 50103 Tartu
Johan Skytte Institute of Political Studies

Faculty link:
skytte.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5582

Faculty email:
skytte [at] ut.ee

Faculty address:
Lossi 36–301, 51003 Tartu
School of Economics and Business Administration

Faculty link:
majandus.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 6310

Faculty email:
majandus [at] ut.ee

Faculty address:
Narva mnt 18, 51009 Tartu
Institute of Psychology

Faculty link:
psychology.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5902

Faculty email:
psyhholoogia [at] ut.ee

Faculty address:
Näituse 2, 50409 Tartu
School of Law

Faculty link:
law.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5390

Faculty email:
oi [at] ut.ee

Faculty address:
Näituse 20–324, 50409 Tartu
Institute of Social Studies

Faculty link:
yti.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5188

Faculty email:
yhiskonnateadused [at] ut.ee

Faculty address:
Lossi 36, 51003 Tartu
Narva College

Faculty link:
www.narva.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 740 1900

Faculty email:
college [at] narva.ut.ee

Faculty address:
Raekoja plats 2, 20307 Narva
Pärnu College

Faculty link:
www.pc.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 445 0520

Faculty email:
info [at] pc.ut.ee

Faculty address:
Ringi 35, 80012 Pärnu

Dean's Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5326

Faculty email:
med [at] ut.ee

Faculty address:
Ravila 19, 50411 Tartu
Institute of Biomedicine and Translational Medicine

Faculty link:
biomeditsiin.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 4210

Faculty email:
bsmi [at] ut.ee

Faculty address:
Biomeedikum, Ravila 19, 50411 Tartu
Institute of Pharmacy

Faculty link:
farmaatsia.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5286

Faculty email:
pharmacy [at] ut.ee

Faculty address:
Nooruse 1, 50411 Tartu
Institute of Dentistry

Faculty link:
hambaarstiteadus.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 731 9856

Faculty address:
Raekoja plats 6, 51003 Tartu
Institute of Clinical Medicine

Faculty link:
clinicalmedicine.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5323

Faculty email:
kmi [at] ut.ee

Faculty address:
L. Puusepa 8, 50406 Tartu
Institute of Family Medicine and Public Health

Faculty link:
tervis.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 4190

Faculty email:
dph [at] ut.ee

Faculty address:
Ravila 19, 50411 Tartu
Institute of Sport Sciences and Physiotherapy

Faculty link:
www.kk.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5360

Faculty email:
kkdek [at] ut.ee

Faculty address:
Jakobi 5–205, 51005 Tartu

Dean's Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5820

Faculty email:
ltt [at] ut.ee

Faculty address:
Vanemuise 46–208, 51003 Tartu
Institute of Computer Science

Faculty link:
cs.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5445

Faculty email:
ics [at] ut.ee

Faculty address:
Narva mnt 18, 51009 Tartu
Estonian Marine Institute

Faculty link:
mereinstituut.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 671 8902

Faculty address:
Mäealuse 14, 12618 Tallinn
Institute of Physics

Faculty link:
www.fi.ut.ee

Faculty contacts link:
Employee contacts

Faculty address:
W. Ostwaldi 1, 50411 Tartu
Institute of Chemistry

Faculty link:
chem.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5261

Faculty email:
chemistry [at] ut.ee

Faculty address:
Ravila 14a, 50411 Tartu
Institute of Genomics

Faculty link:
genomics.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 4000

Faculty email:
egv [at] ut.ee

Faculty address:
Riia 23b, 51010 Tartu
Institute of Mathematics and Statistics

Faculty link:
www.math.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5860

Faculty email:
ltms [at] ut.ee

Faculty address:
Narva mnt 18, 51009 Tartu
Institute of Molecular and Cell Biology

Faculty link:
tymri.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5027

Faculty address:
Riia 23, 23b–134, 51010 Tartu
Tartu Observatory

Faculty link:
www.kosmos.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 4510

Faculty email:
kosmos [at] ut.ee

Faculty address:
Observatooriumi 1, Tõravere, 61602 Tartumaa
Institute of Technology

Faculty link:
tuit.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 4800

Faculty email:
info [at] tuit.ut.ee

Faculty address:
Nooruse 1, 50411 Tartu
Institute of Ecology and Earth Sciences

Faculty link:
www.omi.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5835

Faculty email:
om [at] ut.ee

Faculty address:
Vanemuise 46, 51003 Tartu

Institutions

Library

Faculty link:
utlib.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5702

Faculty email:
library [at] utlib.ee

Faculty address:
W. Struve 1, 50091 Tartu
Youth Academy

Faculty link:
teaduskool.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5581

Faculty email:
teaduskool [at] ut.ee

Faculty address:
Uppsala 10, 51003 Tartu
Museum

Faculty link:
muuseum.ut.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5674

Faculty email:
muuseum [at] ut.ee

Faculty address:
Lossi 25, 51003 Tartu
University of Tartu Natural History Museum and Botanical Garden

Faculty link:
natmuseum.ut.ee

Faculty contacts link:
https://www.ut.ee/en/kontakt/loodusmuuseum-botaanikaaed

Faculty phone:
+372 737 6076

Faculty email:
loodusmuuseum [at] ut.ee

Faculty address:
Vanemuise 46, 51003 Tartu

Support Units

Administrative Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5606

Faculty email:
kantselei [at] ut.ee

Faculty address:
Ülikooli 18a, 51005 Tartu
Centre for Entrepreneurship and Innovation

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 4809

Faculty email:
eik [at] ut.ee

Faculty address:
Narva mnt 18, 51009, Tartu
University Office in Tallinn

Faculty link:
University Office in Tallinn

Faculty contacts link:
Employeescontacts

Faculty phone:
+372 737 6600

Faculty email:
esindus [at] tallinn.ut.ee

Faculty address:
Teatri väljak 3, 10143 Tallinn
Estates Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5137

Faculty address:
Ülikooli 18a, 51005 Tartu
Finance Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5125

Faculty email:
rahandus [at] ut.ee

Faculty address:
Jakobi 4, 51005 Tartu
Grant Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 6215

Faculty address:
Raekoja plats 9, 51004 Tartu
Information Technology Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 6000, IT-help: +372 737 5500

Faculty email:
ito [at] ut.ee, arvutiabi [at] ut.ee

Faculty address:
Ülikooli 18a, 51005 Tartu
Human Resources Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5145

Faculty email:
personal [at] ut.ee

Faculty address:
Ülikooli 18, rooms 302 and 304, 50090 Tartu
Internal Audit Office

Faculty contacts link:
Employee contacts

Faculty email:
siseaudit [at] ut.ee

Faculty address:
Ülikooli 18-244, 51005 Tartu
International Cooperation and Protocol Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 6123

Faculty email:
iro [at] ut.ee

Faculty address:
Ülikooli 18, rooms 104, 301, 305, 50090 Tartu
Marketing and Communication Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5687

Faculty email:
info [at] ut.ee, avalik [at] ut.ee

Faculty address:
Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
Office of Academic Affairs

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5620

Faculty address:
Ülikooli 18, 50090 Tartu
Procurement Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 6632

Faculty email:
tuuli.ilula [at] ut.ee

Faculty address:
Ülikooli 18a, 51005 Tartu
Rector's Office
Rector's Strategy Office

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5600

Faculty email:
rektor [at] ut.ee

Faculty address:
Ülikooli 18, 50090 Tartu
Student Council

Faculty link:
tyye.ut.ee

Faculty contacts link:
Employee contacts

Faculty email:
info [at] tyye.ee

Faculty address:
Ülikooli 18b, 51005 Tartu
University of Tartu Press

Faculty link:
www.tyk.ee

Faculty contacts link:
Employee contacts

Faculty phone:
+372 737 5945

Faculty email:
tyk [at] ut.ee

Faculty address:
W. Struve 1, 50091 Tartu

University of Tartu Academic Sports Club

Faculty link:
sport.ut.ee

Faculty phone:
+372 737 5371

Faculty email:
info [at] tysk.ee

Faculty address:
Ujula 4, 51008 Tartu
Tartu Student Village

Faculty link:
campus.ee

Faculty phone:
+372 740 9959

Faculty email:
info [at] kyla.ee

Faculty address:
Narva mnt 25, 51013 Tartu
Tartu Students’ Club

Faculty link:
www.tym.ee

Faculty phone:
+372 730 2400

Faculty email:
tym [at] ut.ee

Faculty address:
Kalevi 24, 51010 Tartu
Tartu University Hospital

Faculty link:
www.kliinikum.ee/eng

Faculty email:
kliinikum [at] kliinikum.ee

Faculty address:
L. Puusepa 1a, 50406 Tartu
University of Tartu Foundation

Faculty link:
sihtasutus.ut.ee/en

Faculty phone:
+372 737 5852

Faculty email:
triin.vakker [at] ut.ee

Faculty address:
Ülikooli 18, 50090 Tartu
View all other units

Faculty link:
www.ut.ee/en/other-units

Date:

28.08.2019 - 14:15

On 28 August at 14:15 Mikk Puustusmaa will defend his doctoral thesis „On the origin of papillomavirus proteins”.

Supervisors:
Senior Research Fellow in Virology Aare Abroi, Institute of Technology
Professor of Bioinformatics Maido Remm, Institute of Molecular and Cell Biology

Opponent:
Senior Research Fellow Andrew E. Firth, PhD, Department of Pathology, University of Cambridge, Great Britain.

Summary:
Viruses are obligatory intracellular parasites harbouring enormous genetic and biological diversity. Viruses are the most abundant biological entities on Earth. Unlike cellular organisms, viruses have multiple evolutionary origins. While there are many hypotheses how viruses emerged, their exact origin is still unknown. The occurrence of viral protein domains in cellular organisms may give us information about the origin of viruses.

In the current thesis, papillomaviruses (PVs) were used as an example to study the potential origin of a viral family. PVs infect many mammalian species, but also birds, turtles, snakes, and fish. PVs have been of interest due to their association with various cancers. Oncogenic human papillomaviruses (HPVs) are responsible for almost all cases of cervical and anal cancers. In this thesis, various sequence collections were analysed to detect distant homologs to PV protein domains in other organisms. We found that PVs have very weak connections to cellular organisms, as only domains from the E1 replication protein had distant homologs in cellular organisms. However, our study revealed that PVs are evolutionarily related to Polyomaviridae and Parvoviridae family. Both of them shared structural homologs of capsid protein L1 and two domains of replication protein E1.

Viral genomes mainly encode protein-coding genes. Occasionally, some of these genes are fully embedded inside one another. In this thesis, over 300 PV genomes were analysed in silico to detect an embedded gene called E8, located within the E1 gene. The E8 was detected in almost all PV-s, except PVs infecting Sauropsida and fish. As these hosts are evolutionarily older than mammalian species, it confirms that E8 emerged after the divergence of mammals.

The detection of the dual-coding region E8 and other embedded elements needs specific solutions. In this thesis, a web tool called cRegions [http://bioinfo.ut.ee/cRegions/] was developed to detect overlapping genes and other embedded elements in protein-coding genes of viruses.

Location:

Riia 23b/2-105

URL:

hdl.handle.net/10062/64833

Event category:

Defence

M	T	W	T	F	S	S
			1 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	2 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	3 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	4 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”
5 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	6 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	7 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	8 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	9 Kristjan Leben “Long-term diagenetic transformation and carbon sequestration potential of Ca-rich oil shale ash waste deposit sediments” Arnis Paršovs “Estonian Electronic Identity Card and its Security Challenges” Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	10 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	11 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”
12 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	13 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	14 President Toomas Hendrik Ilves: Threats to democracy in the digital era Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	15 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	16 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	17 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	18 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”
19 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	20 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	21 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	22 Tartu International Law Conversations discuss the Nuremberg trials and the Soviet Union Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	23 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	24 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	25 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”
26 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	27 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	28 Mihkel Örd “Ordering the phosphorylation of cyclin-dependent kinase Cdk1 substrates in the cell cycle” Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	29 Kati Klein “Studies and treatment of inhibitory and recalcitrant wastewater” Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	30 Aarne Maasik’s Photos of Tartu Cathedral Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”

Search form

Mikk Puustusmaa „On the origin of papillomavirus proteins”

April