Professor Tamas Bartfai's lecture "Gap between medical need and drug discovery efforts"

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View all other units

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Date:

25.11.2015 - 16:00 to 17:30

Professor Tamas Bartfai

The Scripps Research Institute, La Jolla, CA, USA

Short summary
Pharmaceutical industry spends ca 15 % of its income on research, the highest portion of income in any industry and the product development time is ca 10 years and the capital needed per approved drug is ca 1.2 bUSD, also the development of drugs is the most regulated human activity. The largest expenditures in drug development are made by private pharmaceutical companies and they focus on the largest markets which are still USA and Europe although the Chinese and Indian middle class numbers now 400 mUSD or more people thus the companies chose to work on rare diseases - oncology, diabetes and cardiovascular diseases. At the same time most large companies stopped research in pain and stopped efforts to develop new antipsychotics, and drugs to slow progression or to stop Alzheimer’s disease and almost none is investing in malaria medicine despite of the disease affecting the largest number of people albeit living in low income countries.
The reasons have to do with the companies need for relatively safe projects which result in approvable and high cost drugs and do not have 3- or 4-year long clinical trials as e.g. in case of Alzheimer’s disease. Also scientists have their serious responsibility. One of the reasons for popularity of oncology as therapeutic area is our understanding of the cellular and molecular mechanisms of different cancers, and thus of the wealth of molecular drug targets that were discovered. We have no similar understanding of schizophrenia, or neuropathic pain. As a result, pain research has been mostly stopped because of the lack of good molecular targets and of reliable, translatable models, so the last 9 pain drugs that failed in the clinical trials were all working in the preclinical models, meaning that these models are useless. Governments who pay for most of the basic research, and indirectly also for the medicines, can affect this development.

Cf. : Future of Drug Development by Bartfai and Lees, Elsevier, 2013, English, Mandarin, Japanese at Amazon.com

Organizer:

Rita Hade

Location:

UT Assembly Hall

Event category:

Lecture

M	T	W	T	F	S	S
	1 Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	2 Gaygysyz Ashyrov „Essays on firm-level corruption” Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	3 Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	4 Kärt Ukkivi “Mutagenic effect of transcription and transcription-coupled repair factors in Pseudomonas putida” Ida Rahu „Bromine formation in inorganic bromide/nitrate mixtures and its application for oxidative aromatic bromination” Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	5 Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	6 Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral
7 The inaugural lecture by Gholamreza Anbarjafari, UT Professor of of Computer Vision The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	8 The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	9 Kadi Luht-Kallas „Risk-taking behaviour: Relationship with personality and markers of heritability, and an intervention to prevent unintentional injury“ The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	10 Larisa Ivanova “Design of active compounds against neurodegenerative diseases” The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	11 The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	12 The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	13 The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral
14 The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	15 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	16 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	17 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	18 Sten Saar "Epidemiology of severe injuries in Estonia" Kadi Tilk „Signals and responses of ColRS two-component system in Pseudomonas putida“ Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	19 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	20 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral
21 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	22 Ilya Kuzovkin „Understanding Information Processing in Human Brain by Interpreting Machine Learning Models“ Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	23 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	24 UT Memorial Day Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	25 Orlenys López Pintado “Collaborative Business Process Execution on the Blockchain: The Caterpillar System“ Mari Urb "DNA methylation in the predisposition, expression and abstinence of cocaine addiction" Researchers' Night Festival: Toome science-themed adventure town special Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	26 Researchers' Night Festival and Day of Countryside Living at Tartu Observatory Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	27 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral
28 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	29 Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral	30 Concert: smooth harmonies Matti Vainio's exhibition "Findings \| Leiud" The Exhibition "The enchanting art of stone cutting. Morgenstern 250" Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu” Aarne Maasik’s Photos of Tartu Cathedral

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Professor Tamas Bartfai's lecture "Gap between medical need and drug discovery efforts"

September