Rene Randver “Parkinson’s disease and depression: brain mechanisms and non-invasive brain stimulation based treatment strategies” | University of Tartu

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Contacts of UT units

Faculty of Arts and Humanities
Faculty phone: 
+372 737 5341
Faculty address: 
Jakobi 2, rooms 116–121, 51005 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5341
    Faculty address: 
    Jakobi 2, rooms 116–121, 51005 Tartu
  • Institute of History and Archaeology
    Faculty phone: 
    +372 737 5651
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Estonian and General Linguistics
    Faculty phone: 
    +372 737 5221
    Faculty address: 
    Jakobi 2, 51005 Tartu
  • Institute of Philosophy and Semiotics
    Faculty phone: 
    +372 737 5314
    Faculty address: 
    Jakobi 2, rooms 309–352, 51005 Tartu
  • Institute of Cultural Research
    Faculty phone: 
    (+372) 737 5223
    Faculty address: 
    Ülikooli 16, 51003 Tartu
  • School of Theology and Religious Studies
    Faculty phone: 
    +372 737 5301
    Faculty address: 
    Ülikooli 18–310, 50090 Tartu
  • College of Foreign Languages and Cultures
    Faculty address: 
    J. Liivi 4, 50409, Tartu
  • Viljandi Culture Academy
    Faculty phone: 
    +372 435 5232
    Faculty address: 
    Posti 1, 71004 Viljandi
Faculty of Social Sciences
Faculty phone: 
+372 737 5957
Faculty address: 
Lossi 36, 51003 Tartu
  • Dean's Office
    Faculty phone: 
    + 372 737 5900
    Faculty address: 
    Lossi 36, 51003 Tartu
  • Institute of Education
    Faculty phone: 
    +372 737 6440
    Faculty address: 
    Salme 1a–29, 50103 Tartu
  • Johan Skytte Institute of Political Studies
    Faculty phone: 
    +372 737 5582
    Faculty address: 
    Lossi 36–301, 51003 Tartu
  • School of Economics and Business Administration
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    +372 737 6310
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Psychology
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    Näituse 2, 50409 Tartu
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  • Institute of Social Studies
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  • Narva College
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  • Pärnu College
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Faculty of Medicine
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+372 737 5326
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Ravila 19, 50411 Tartu
  • Dean's Office
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Biomedicine and Translational Medicine
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    Biomeedikum, Ravila 19, 50411 Tartu
  • Institute of Pharmacy
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    Nooruse 1, 50411 Tartu
  • Institute of Dentistry
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  • Institute of Clinical Medicine
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    L. Puusepa 8, 50406 Tartu
  • Institute of Family Medicine and Public Health
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    Faculty address: 
    Ravila 19, 50411 Tartu
  • Institute of Sport Sciences and Physiotherapy
    Faculty phone: 
    +372 737 5360
    Faculty address: 
    Jakobi 5–205, 51005 Tartu
Faculty of Science and Technology
Faculty phone: 
+372 737 5820
Faculty address: 
Vanemuise 46–208, 51014 Tartu
  • Dean's Office
    Faculty phone: 
    +372 737 5820
    Faculty address: 
    Vanemuise 46–208, 51003 Tartu
  • Institute of Computer Science
    Faculty phone: 
    +372 737 5445
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Estonian Marine Institute
    Faculty phone: 
    +372 671 8902
    Faculty address: 
    Mäealuse 14, 12618 Tallinn
  • Institute of Physics
    Faculty address: 
    W. Ostwaldi 1, 50411 Tartu
  • Institute of Chemistry
    Faculty phone: 
    +372 737 5261
    Faculty address: 
    Ravila 14a, 50411 Tartu
  • Institute of Genomics
    Faculty phone: 
    +372 737 4000
    Faculty address: 
    Riia 23b, 51010 Tartu
  • Institute of Mathematics and Statistics
    Faculty phone: 
    +372 737 5860
    Faculty address: 
    Narva mnt 18, 51009 Tartu
  • Institute of Molecular and Cell Biology
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    +372 737 5027
    Faculty address: 
    Riia 23, 23b–134, 51010 Tartu
  • Tartu Observatory
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    Faculty address: 
    Observatooriumi 1, Tõravere, 61602 Tartumaa
  • Institute of Technology
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    Faculty address: 
    Nooruse 1, 50411 Tartu
  • Institute of Ecology and Earth Sciences
    Faculty phone: 
    +372 737 5835
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Institutions
  • Library
    Faculty phone: 
    +372 737 5702
    Faculty address: 
    W. Struve 1, 50091 Tartu
  • Youth Academy
    Faculty phone: 
    +372 737 5581
    Faculty address: 
    Uppsala 10, 51003 Tartu
  • Museum
    Faculty phone: 
    +372 737 5674
    Faculty address: 
    Lossi 25, 51003 Tartu
  • University of Tartu Natural History Museum and Botanical Garden
    Faculty phone: 
    +372 737 6076
    Faculty address: 
    Vanemuise 46, 51003 Tartu
Support Units
  • Administrative Office
    Faculty phone: 
    +372 737 5606
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Centre for Entrepreneurship and Innovation
    Faculty phone: 
    +372 737 4809
    Faculty address: 
    Narva mnt 18, 51009, Tartu
  • University Office in Tallinn
    Faculty phone: 
    +372 737 6600
    Faculty address: 
    Teatri väljak 3, 10143 Tallinn
  • Estates Office
    Faculty phone: 
    +372 737 5137
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Finance Office
    Faculty phone: 
    +372 737 5125
    Faculty address: 
    Jakobi 4, 51005 Tartu
  • Grant Office
    Faculty phone: 
    +372 737 6215
    Faculty address: 
    Raekoja plats 9, 51004 Tartu
  • Information Technology Office
    Faculty phone: 
    +372 737 6000, IT-help: +372 737 5500
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Human Resources Office
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    +372 737 5145
    Faculty address: 
    Ülikooli 18, rooms 302 and 304, 50090 Tartu
  • Internal Audit Office
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    Ülikooli 18-244, 51005 Tartu
  • International Cooperation and Protocol Office
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    +372 737 6123
    Faculty address: 
    Ülikooli 18, rooms 104, 301, 305, 50090 Tartu
  • Marketing and Communication Office
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    +372 737 5687
    Faculty address: 
    Ülikooli 18, rooms 102, 104, 209, 210, 50090 Tartu
  • Office of Academic Affairs
    Faculty phone: 
    +372 737 5620
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Procurement Office
    Faculty phone: 
    +372 737 6632
    Faculty address: 
    Ülikooli 18a, 51005 Tartu
  • Rector's Strategy Office
    Faculty phone: 
    +372 737 5600
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • Student Council
    Faculty address: 
    Ülikooli 18b, 51005 Tartu
  • University of Tartu Press
    Faculty phone: 
    +372 737 5945
    Faculty address: 
    W. Struve 1, 50091 Tartu
Other Units
  • University of Tartu Academic Sports Club
    Faculty phone: 
    +372 737 5371
    Faculty address: 
    Ujula 4, 51008 Tartu
  • Tartu Student Village
    Faculty phone: 
    +372 740 9959
    Faculty address: 
    Narva mnt 25, 51013 Tartu
  • Tartu Students’ Club
    Faculty phone: 
    +372 730 2400
    Faculty address: 
    Kalevi 24, 51010 Tartu
  • Tartu University Hospital
    Faculty address: 
    L. Puusepa 1a, 50406 Tartu
  • University of Tartu Foundation
    Faculty phone: 
    +372 737 5852
    Faculty address: 
    Ülikooli 18, 50090 Tartu
  • View all other units

Rene Randver “Parkinson’s disease and depression: brain mechanisms and non-invasive brain stimulation based treatment strategies”

Date: 
15.10.2021 - 12:15

On 15 October at 12:15 Rene Randver will defend his doctoral thesis “Parkinson’s disease and depression: brain mechanisms and non-invasive brain stimulation based treatment strategies” (in Psychology).

Supervisor:
Professor Talis Bachmann, University of Tartu

 
Opponent:
Maria Pąchalska, MD, PhD, Professor Andrzej Frycz Modrzewski Krakow University  (Poland)

Summary
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. PD is characterized by motor and non-motor features, the latter including neuropsychiatric disorders. Neuropsychiatric disorders (such as emotional and cognitive symptoms) are common in PD and have a significant impact on a person's quality of life. Worldwide, up to 50% of PD patients have clinically significant depressive symptoms, which is higher in prevalence than in the general population (estimated at 13.5%). A large proportion of patients do not achieve complete remission during treatment for neuropsychiatric disorders for a variety of reasons, including treatment-related causes such as inappropriate treatment options, side effects of treatment, interactions with other drugs, contraindications, premature discontinuation of treatment, and others. Non-invasive brain stimulation methods such as repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC), have been shown to safely and effectively alleviate emotional, and to a lesser extent, cognitive, problems. The main objective of this doctoral dissertation was to gather and expand the knowledge on the application of effective rTMS treatment in patients diagnosed with both PT and depression, also being mindful of potential neuropsychiatric effects outside the mood domain (i.e. cognitive problems and anxiety).

The following statements can be stated to summarize the research of the dissertation:

1.    The severity of depressive symptoms is an important factor influencing the clinical aspects of PD, and the quality of life of patients. Neuroanatomical changes in the raphe nuclei of the brainstem are directly related to the pathogenesis of depressive disorders and underline the growing importance and diagnostic applicability of brain-based biomarkers of depression in the context of PD.

2.    Targeting the DLPFC with rTMS is an effective treatment strategy for PD-related depression, with the potential for positive effects on other neuropsychiatric problems (e.g., cognitive impairment, anxiety disorders, apathy), the latter of which will need to be confirmed in future clinical trials.

3.    PD patients with treatment-resistant depression represent a complex clinical sample with many, often insufficiently covered, treatment needs, emphasizing individual variability in both clinical status and potential treatment response, thereby justifying personalized treatment interventions that include rTMS as a standalone method and in combination with others.

Organizer: 
Kertu Saar
Location: 
Näituse 2–102, Tartu and Zoom
Event category: