Xuan Dung Ho „Characterization of the genomic profile of osteosarcoma“

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View all other units

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Date:

04.12.2018 - 15:00

On 4 December at 15 Xuan Dung Ho will defend his doctoral thesis „Characterization of the genomic profile of osteosarcoma“.

Supervisors:
Professor Aare Märtson (dr. med. (arstiteadus)), Institute of Clinical Medicine , University of Tartu
Professor Sulev Kõks (PhD (molekulaarne biomeditsiin)), Institute of Biomedicine and Translational Medicine, University of Tartu
Associate Professor Katre Maasalu (dr. med. (arstiteadus)), Institute of Clinical Medicine , University of Tartu

Opponent:
Professor Thomas Rado (PhD), Kadlec Clinic Hematology & Oncology, University of Washington, Seattle, WA, USA

Summary:
Osteosarcoma (OS) is the most frequent type of primary bone cancer. About 3 cases per million population are diagnosed each year. It especially affects the young around puberty with slightly higher prevalence in male than in the female. The complaints of affected patients are very unspecific. Hence, the disease is easily neglected by the primary care doctors. Femur, tibia, and humerus are the most common sites of OS. It is a highly metastasized disease and lung is the most preferable metastatic site. The introduction of chemotherapy in the late 70s and early 80s has clearly improved the survival rate of OS and makes it possible for conservative operation. However, the prognosis of OS is still poor and unchanged since the 1980s. The cause and mechanism of OS are still poorly understood.

The number of studies on OS is growing dramatically with aims to understand its mechanism and to seek new therapeutic targets. Recently, genomic alterations in OS were studied with modern techniques. The differential expression of genes in OS has been reported with diverse findings, which may be due to the diversity of OS or design-associated limitations such as a small number of study subjects, variations in control groups, different laboratory protocols, and analysis techniques. We tried to overcome the present common limitations by analyzing paired samples of tumoral vs non-tumoral fresh bone specimens from the same patient and the paraffin blocks with RNA sequencing technique. Over 5000 genes were found to be differentially expressed between the normal and OS tissues. The most significantly differentially expressed genes were recognized to be further studied. The degradation of collagen seems to be an important mechanism of OS and should be further evaluated to serve as a biomarker for OS. The repetitive elements SAR, HSATII, and simple repeat (CATTC)n which were overexpressed in carcinoma in previous studies were also upregulated in OS and should be evaluated for biomarkers of this disease.

Location:

Ravila 19-1006

URL:

hdl.handle.net/10062/62523

Event category:

Defence

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14 Toomas Toomsoo „Transcranial brain sonography in the Estonian cohort of Parkinson’s disease“ Full moon exploring session (in case the sky is clear) Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	15 Lidiia Zhytnik „Inter- and intrafamilial diversity based on genotype and phenotype correlations of Osteogenesis Imperfecta“ Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	16 Restart a heart day in Lossi 36 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	17 Karin Ernits „Levansucrase Lsc3 and endo-levanase BT1760: characterization and application for the synthesis of novel prebiotics” Astronomy seminar: The Research of This Year's Nobel Prize Winners and Their Connection to the UT Tartu Observatory UT Professor in Developmental Biology Osamu Shimmi inaugural lecture “Cellular dynamics and signalling in tissue development: lessons from fruit fly Drosophila melanogaster” Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests”	18 International seminar „Labour market integration on newly arrived immigrants“ Anni Rava „Associations between body composition, mobility and blood inflammatory biomarkers with physical activity in healthy older women“ Estonia's National University 100: “One hundred faces of the University of Tartu” Estonia's National University 100: "Book presentation “Academic Freedom: Studentdom of the University of Tartu through the ages” Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	19 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	20 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”
21 Sille Holm „Comparative ecology of geometrid moths: in search of contrasts between a temperate and a tropical forest“ Dagmar Narusson „Personaalset taastumist ja agentsust toetav klienditöö vaimse tervise ja sotsiaalse rehabilitatsiooni valdkonnas: vaimse tervise raskustega inimeste ja spetsialistide perspektiivid“ Mari Schihalejev „Debtor-Related Creditors’ Claims in Insolvency Proceedings“ Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	22 Pilleriin Soodla „Newly HIV infected people in Estonia: estimation of incidence and transmitted drug resistance“ Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	23 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	24 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	25 Anneliis Peterson „Benthic biodiversity in the north-eastern Baltic Sea: mapping methods, spatial patterns, and relations to environmental gradients“ Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	26 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	27 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”
28 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	29 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	30 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”	31 Exhibition “Tartu – Rendezvous of Cultures” Exhibition "The University of Tartu Main Building in Art" The Exhibition "The University of Tartu Main Building in Art" Exhibition dedicated to the Estonian national university “Estonia of Ideals. 100 Years of Quests” Estonia's National University 100: Photo exhibition “Put on Your Thinking Cap! The Hundred Faces of the University of Tartu”

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Xuan Dung Ho „Characterization of the genomic profile of osteosarcoma“

October